Colotla V A
Neurosci Biobehav Rev. 1981 Fall;5(3):335-42. doi: 10.1016/0149-7634(81)90028-2.
Schedule-induced polydipsia or adjunctive drinking as been proposed as an animal model of alcoholism. Procedures employed to modify adjunctive drinking are reviewed here in order to evaluate their usefulness in the control of schedule-induced alcohol consumption. The major procedures employed to alter adjunctive drinking are: (1) physiological, such as pre-loading the animal with water, desalivating the animal, or adding a sweet solution to the water; (2) pharmacological, such as evaluating the effects of amphetamines or other drugs on adjunctive drinking; and (3) behavioral, such as changing the inter-reinforcement interval length, making an alternative response available, or giving the animal the option to terminate an extinction period. Altering the palatability of alcohol and utilizing behavioral methods to control drinking appear to be the most promising lines of investigation employing this animal model of alcoholism.
程序诱导的烦渴或辅助性饮水已被提议作为酒精中毒的动物模型。本文回顾了用于改变辅助性饮水的程序，以评估它们在控制程序诱导的酒精消费方面的有用性。用于改变辅助性饮水的主要程序有：（1）生理方面的，如给动物预先饮水、使动物唾液减少或在水中添加甜味溶液；（2）药理学方面的，如评估安非他明或其他药物对辅助性饮水的影响；以及（3）行为方面的，如改变强化间隔时间长度、提供替代反应或让动物选择终止消退期。改变酒精的适口性并利用行为方法来控制饮酒似乎是采用这种酒精中毒动物模型最有前景的研究方向。
