大鼠脑中牛胰多肽样免疫反应性神经元的分布。

The distribution of bovine pancreatic polypeptide-like immunoreactive neurons in rat brain.

作者信息

Olschowka J A, O'Donohue T L, Jacobowitz D M

出版信息

Peptides. 1981 Fall;2(3):309-31. doi: 10.1016/s0196-9781(81)80125-8.

Abstract

Using the indirect immunofluorescent technique, bovine pancreatic polypeptide (BPP)-like immunoreactive nerve fibers and cell bodies were observed widely distributed in rat brain. A detailed stereotaxic atlas of BPP-immunoreactive neurons was prepared. Large numbers of BPP-containing perikarya were observed in the acute nucleus, with scattered cells in the cerebral cortex, nucleus olfactorius anterior, nucleus tractus diagonalis, olfactory tubercle, nucleus accumbens, neostriatum, nucleus interstitialis stria terminalis, nucleus preopticus medialis, area retrochiasmatica, zona interna of the median eminence, substantia grisea centralis, locus coeruleus, nucleus tractus solitarius, and in the region of the nucleus reticularis lateralis. Large numbers of varicose BPP-like nerve fibers were observed in the following nuclei: accumbens, interstitialis stria terminalis, preopticus medialis, preopticus suprachiasmaticus, suprachiasmaticus, periventricular thalamic and hypothalamic, paraventricularis, dorsomedialis, ventromedialis, arcuatus, parabrachialis dorsalis, tractus solitarius and the substantia gelatinosa trigemini. The present findings suggest that a BPP-like peptide may be involved in significant neuronal circuitry, possibly in a neurotransmitter or neuromodulator role. However, the exact identity of this peptide and its physiological role remain to be determined.

摘要

运用间接免疫荧光技术，观察到牛胰多肽（BPP）样免疫反应性神经纤维和细胞体广泛分布于大鼠脑内。制备了一份详细的BPP免疫反应性神经元立体定位图谱。在杏仁核中观察到大量含BPP的核周体，在大脑皮层、嗅前核、斜角带核、嗅结节、伏隔核、新纹状体、终纹床核间部、视前内侧核、视交叉后区、正中隆起内侧区、中央灰质、蓝斑、孤束核以及外侧网状核区域有散在细胞。在以下核团中观察到大量曲张的BPP样神经纤维：伏隔核、终纹床核间部、视前内侧核、视交叉上视前核、视交叉上核、室周丘脑和下丘脑、室旁核、背内侧核、腹内侧核、弓状核、背侧臂旁核、孤束和三叉神经胶状质。目前的研究结果表明，一种BPP样肽可能参与重要的神经回路，可能发挥神经递质或神经调质的作用。然而，这种肽的确切身份及其生理作用仍有待确定。