黏膜前列腺素和DNA合成在腔内表皮生长因子对胃细胞保护中的作用。
Role of mucosal prostaglandins and DNA synthesis in gastric cytoprotection by luminal epidermal growth factor.
作者信息
Konturek S J, Brzozowski T, Piastucki I, Dembinski A, Radecki T, Dembinska-Kiec A, Zmuda A, Gregory H
出版信息
Gut. 1981 Nov;22(11):927-32. doi: 10.1136/gut.22.11.927.
Abstract
This study compares the effect of epidermal growth factor and prostaglandins (PGE2 or PGI2), applied topically to gastric mucosa, on gastric secretion and formation of ASA-induced gastric ulcerations in rats. Epidermal growth factor given topically in non-antisecretory doses prevented dose-dependently the formation of ASA-induced ulcers without affecting prostaglandin generation but with a significant rise in DNA synthesis in the oxyntic mucosa. The anti-ulcer effect of topical prostaglandins was also accompanied by an increase in DNA synthesis. This study indicates that topical epidermal growth factor, like PGE2 or PGI2, is cytoprotective and that this cytoprotection is not mediated by the inhibition of gastric secretion or prostaglandin formation but related to the increase in DNA synthesis in oxyntic mucosa.
摘要
本研究比较了局部应用于大鼠胃黏膜的表皮生长因子和前列腺素（PGE2或PGI2）对胃分泌及阿司匹林诱导的胃溃疡形成的影响。以非抗分泌剂量局部给予表皮生长因子可剂量依赖性地预防阿司匹林诱导的溃疡形成，且不影响前列腺素的生成，但可使胃黏膜DNA合成显著增加。局部应用前列腺素的抗溃疡作用也伴有DNA合成增加。本研究表明，局部应用表皮生长因子与PGE2或PGI2一样具有细胞保护作用，且这种细胞保护作用不是通过抑制胃分泌或前列腺素形成介导的，而是与胃黏膜DNA合成增加有关。
相似文献
1
Role of mucosal prostaglandins and DNA synthesis in gastric cytoprotection by luminal epidermal growth factor.黏膜前列腺素和DNA合成在腔内表皮生长因子对胃细胞保护中的作用。
Gut. 1981 Nov;22(11):927-32. doi: 10.1136/gut.22.11.927.
2
Gastric cytoprotection by epidermal growth factor. Role of endogenous prostaglandins and DNA synthesis.表皮生长因子对胃的细胞保护作用。内源性前列腺素和DNA合成的作用。
Gastroenterology. 1981 Sep;81(3):438-43.
3
Gastric cytoprotection by pirenzepine. Role of endogenous prostaglandins.哌仑西平对胃的细胞保护作用。内源性前列腺素的作用。
Scand J Gastroenterol Suppl. 1982;72:255-9.
4
Role of epidermal growth factor, prostaglandin, and sulfhydryls in stress-induced gastric lesions.表皮生长因子、前列腺素和巯基在应激性胃损伤中的作用
Gastroenterology. 1990 Dec;99(6):1607-15. doi: 10.1016/0016-5085(90)90464-c.
5
Gastric cytoprotection by acetazolamide: role of endogenous prostaglandins.乙酰唑胺对胃的细胞保护作用：内源性前列腺素的作用
Digestion. 1983;28(2):125-31. doi: 10.1159/000198975.
6
Protective effects of the prostaglandins on the gastric mucosa.前列腺素对胃黏膜的保护作用。
Am J Med. 1986 Aug 18;81(2A):2-4. doi: 10.1016/s0002-9343(86)80002-x.
7
Gastric cytoprotection by prostaglandins, ranitidine, and probanthine in rats. Role of endogenous prostaglandins.前列腺素、雷尼替丁和丙胺太林对大鼠胃的细胞保护作用。内源性前列腺素的作用。
Scand J Gastroenterol. 1981;16(1):7-12.
8
Prostaglandins and gastric mucosal protection by esaprazole in rats.前列腺素与埃索美拉唑对大鼠胃黏膜的保护作用
Eur J Pharmacol. 1990 Oct 2;187(1):19-25. doi: 10.1016/0014-2999(90)90336-5.
9
Central nervous system effects of arachidonic acid, PGE2, PGF2 alpha, PGD2 and PGI2 on gastric secretion in the rat.花生四烯酸、前列腺素E2、前列腺素F2α、前列腺素D2和前列环素对大鼠胃分泌的中枢神经系统效应
Br J Pharmacol. 1983 Oct;80(2):255-62. doi: 10.1111/j.1476-5381.1983.tb10028.x.
10
Comparison of prostacyclin and prostaglandin E2 on gastric secretion, gastrin release, and mucosal blood flow in dogs.前列环素与前列腺素E2对犬胃分泌、胃泌素释放及黏膜血流的比较
Dig Dis Sci. 1980 Sep;25(9):673-9. doi: 10.1007/BF01308326.
引用本文的文献
1
A Novel Combination of Wheat Peptides and Fucoidan Attenuates Ethanol-Induced Gastric Mucosal Damage through Anti-Oxidant, Anti-Inflammatory, and Pro-Survival Mechanisms.小麦肽与岩藻多糖的新型组合通过抗氧化、抗炎和促进生存机制减轻乙醇诱导的胃黏膜损伤。
Nutrients. 2017 Sep 6;9(9):978. doi: 10.3390/nu9090978.
2
Prostacyclin prevents nitric oxide-induced megakaryocyte apoptosis.前列环素可预防一氧化氮诱导的巨核细胞凋亡。
Br J Pharmacol. 2005 Jun;145(3):283-92. doi: 10.1038/sj.bjp.0706200.
3
Comparison of the antisecretory and antiulcer activity of epidermal growth factor, urogastrone and transforming growth factor alpha and its derivative in rodents in vivo.表皮生长因子、尿抑胃素、转化生长因子α及其衍生物在啮齿动物体内的抗分泌和抗溃疡活性比较
Mol Cell Biochem. 2002 Jul;236(1-2):83-94. doi: 10.1023/a:1016144016908.
4
Effects of epidermal growth factor and insulin on migration and proliferation of primary cultured rabbit gastric epithelial cells.表皮生长因子和胰岛素对原代培养兔胃上皮细胞迁移和增殖的影响。
J Gastroenterol. 1997 Oct;32(5):573-8. doi: 10.1007/BF02934104.
5
Epidermal growth factor, polyamines, and prostaglandins in healing of stress-induced gastric lesions in rats.表皮生长因子、多胺和前列腺素在大鼠应激性胃损伤愈合中的作用
Dig Dis Sci. 1993 Feb;38(2):276-83. doi: 10.1007/BF01307544.
6
Effects of epidermal growth factor on alkaline secretion and mucus formation in rat duodenum exposed to luminal acid.表皮生长因子对暴露于腔内酸的大鼠十二指肠碱性分泌和黏液形成的影响。
Gastroenterol Jpn. 1993 Aug;28(4):496-504. doi: 10.1007/BF02776947.
7
Influence of gastric pH modifiers on development of intestinal metaplasia induced by X-irradiation in rats.胃pH调节剂对大鼠X射线诱导的肠化生发展的影响。
Jpn J Cancer Res. 1993 Oct;84(10):1037-42. doi: 10.1111/j.1349-7006.1993.tb02798.x.
8
Localization of epidermal growth factor/transforming growth factor-alpha receptor in the human gastric mucosa. An immunohistochemical and in situ hybridization study.人胃黏膜中表皮生长因子/转化生长因子-α受体的定位。一项免疫组织化学和原位杂交研究。
Virchows Arch A Pathol Anat Histopathol. 1993;423(1):57-63. doi: 10.1007/BF01606433.
9
Epidermal growth factor enhances repair of rat intestinal mucosa damaged by oral administration of methotrexate.表皮生长因子可增强口服甲氨蝶呤所致大鼠肠黏膜损伤的修复。
J Gastroenterol. 1995 Apr;30(2):169-76. doi: 10.1007/BF02348661.
10
Epidermal growth factor in saliva and gastric juice: response to histamine.唾液和胃液中的表皮生长因子：对组胺的反应。
Gut. 1995 Sep;37(3):335-9. doi: 10.1136/gut.37.3.335.
本文引用的文献
1
POSSIBLE SYNTHESIS OF POLYRIBONUCLEOTIDES OF KNOWN BASE-TRIPLET SEQUENCES.已知碱基三联体序列的多核糖核苷酸的可能合成
Nature. 1965 Apr 3;206:93. doi: 10.1038/206093b0.
2
Response of the chronic gastric fistula rat to histamine.慢性胃瘘大鼠对组胺的反应。
Am J Physiol. 1957 Aug;190(2):221-8. doi: 10.1152/ajplegacy.1957.190.2.221.
3
A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.用于比色法测定脱氧核糖核酸的二苯胺反应的条件及机制研究。
Biochem J. 1956 Feb;62(2):315-23. doi: 10.1042/bj0620315.
4
Role of prostaglandins in the formation of aspirin-induced gastric ulcers.前列腺素在阿司匹林所致胃溃疡形成中的作用。
Gastroenterology. 1981 Jan;80(1):4-9.
5
Decreased incidence of restraint-stress induced gastric erosions in rats treated with bovine growth hormone.用牛生长激素治疗的大鼠中，束缚应激诱导的胃糜烂发生率降低。
Proc Soc Exp Biol Med. 1970 Nov;135(2):259-62. doi: 10.3181/00379727-135-35032.
6
Epidermal growth factor and a new derivative. Rapid isolation procedures and biological and chemical characterization.表皮生长因子及一种新衍生物。快速分离方法以及生物学和化学特性
J Biol Chem. 1972 Dec 10;247(23):7609-11.
7
Recent studies on the chemistry and biology of epidermal growth factor.近期关于表皮生长因子化学与生物学的研究。
Recent Prog Horm Res. 1974;30(0):551-74. doi: 10.1016/b978-0-12-571130-2.50018-3.
8
Isolation and structure of urogastrone and its relationship to epidermal growth factor.尿抑胃素的分离、结构及其与表皮生长因子的关系。
Nature. 1975 Sep 25;257(5524):325-7. doi: 10.1038/257325a0.
9
Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides.动脉壁可通过一种由前列腺素内过氧化物生成的物质（前列腺素X）来防止血小板血栓的沉积。
Prostaglandins. 1976 Nov;12(5):685-713. doi: 10.1016/0090-6980(76)90047-2.
Zotero 插件