洪都拉斯乔卢特卡恶性疟原虫氯喹敏感性评估
Assessment of chloroquine sensitivity of Plasmodium falciparum in Choluteca, Honduras.
作者信息
Nguyen-Dinh P, Hobbs J H, Campbell C C
出版信息
Bull World Health Organ. 1981;59(4):641-6.
Abstract
During an outbreak of urban malaria in Choluteca, Honduras, the response of local isolates of Plasmodium falciparum to chloroquine was assessed. The 7-day WHO alternative standard field test was used together with three in vitro tests: the Rieckmann macro- and micromethods and a new 48-hour test which underwent its first field trial in this study. No chloroquine resistance was found in in vivo tests in 10 patients or in the in vitro tests on blood samples from 6 patients.
摘要
在洪都拉斯乔卢特卡市爆发城市疟疾期间，对当地恶性疟原虫分离株对氯喹的反应进行了评估。采用了世界卫生组织7天替代标准现场试验以及三项体外试验：里克曼宏观和微观方法，以及一项新的48小时试验，该试验在本研究中进行了首次现场试验。在10名患者的体内试验以及6名患者血样的体外试验中均未发现氯喹耐药性。
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