耐氯喹恶性疟原虫对甲氟喹的体外反应
In vitro response of chloroquine-resistant Plasmodium falciparum to mefloquine.
作者信息
López Antuñano F J, Wernsdorfer W H
出版信息
Bull World Health Organ. 1979;57(4):663-5.
Abstract
The present study was conducted to evaluate the application of the in vitro microtechnique system in determining the response of chloroquine-resistant Plasmodium falciparum to mefloquine.Using isolates of P. falciparum from Boa Vista, Brazil, and Villavicencio, Colombia, mefloquine was more than 7.7, 7.1, 7.1, and 6.4 times more effective than chloroquine in vitro at the ED(90), ED(95), ED(99), and ED(99.9) levels, respectively.
摘要
本研究旨在评估体外微技术系统在确定氯喹抗性恶性疟原虫对甲氟喹的反应中的应用。使用来自巴西博阿维斯塔和哥伦比亚比亚维森西奥的恶性疟原虫分离株，在ED(90)、ED(95)、ED(99)和ED(99.9)水平下，甲氟喹在体外的有效性分别比氯喹高7.7倍、7.1倍、7.1倍和6.4倍。
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2
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