Magloire R, Nguyen-Dinh P
Bull World Health Organ. 1983;61(6):1017-20.
In January and February 1982, in vivo and in vitro studies of the chloroquine sensitivity of Plasmodium falciparum were conducted in Port-au-Prince, Haiti. Of 19 infections tested in vivo using the WHO extended test, all but one were susceptible to the drug; the remaining case showed a recurrence of parasitaemia on day 28. Of the 19 corresponding 48-hour in vitro tests, 16 provided interpretable results; 12 tests demonstrated sensitivity to the drug, while in the remaining 4, parasite multiplication was inhibited only at drug concentrations higher than that previously accepted as indicative of sensitivity. (These four included the isolate from the patient who had a recurrence of parasitaemia on day 28.) While these results provide no absolute demonstration of chloroquine resistance, they underline the need for close monitoring of the susceptibility to chloroquine of P. falciparum in Haiti.
1982年1月和2月，在海地太子港对恶性疟原虫的氯喹敏感性进行了体内和体外研究。在使用世界卫生组织扩展试验进行的19例体内感染检测中，除1例之外其余均对该药物敏感；其余病例在第28天出现了寄生虫血症复发。在19项相应的48小时体外试验中，16项得出了可解释的结果；12项试验表明对该药物敏感，而在其余4项试验中，仅在药物浓度高于先前认为表明敏感的浓度时，寄生虫增殖才受到抑制。（这4例包括第28天出现寄生虫血症复发患者的分离株。）虽然这些结果并未绝对证明存在氯喹耐药性，但它们强调了密切监测海地恶性疟原虫对氯喹敏感性的必要性。
