人体班氏吴策线虫感染诊断中的抗体测定
Antibody determination in the diagnosis of Wuchereria bancrofti infection in man.
作者信息
Dissanayake S, Ismail M M
出版信息
Bull World Health Organ. 1981;59(5):753-7.
The levels of IgG and IgE antibodies reacting with somatic antigens of adult Setaria digitata and Wuchereria bancrofti microfilariae were determined in sera of 90 patients with Bancroftian filariasis and 379 non-filarial subjects. Antibodies reacting with adult antigens and with soluble microfilarial antigens were seen in both microfilaraemic and amicrofilaraemic patients. Antibodies reacting with surface antigens of W. bancrofti microfilariae were seen only in amicrofilaraemic subjects. IgE antibodies were detected with the adult antigen only in both microfilaraemic and amicrofilaraemic patients. The absolute levels of IgG antibodies were significantly higher than those of IgE antibodies. It is concluded that the determination of serum antibodies reacting with adult antigens is suitable for the diagnosis of both the microfilaraemic and amicrofilaraemic phases of infection, and the determination of antibody to microfilarial surface antigens is applicable in patients with clinically evident disease.
在90例班氏丝虫病患者和379例非丝虫病患者的血清中，测定了与成年指状腹腔丝虫和班氏吴策线虫微丝蚴体细胞抗原发生反应的IgG和IgE抗体水平。在有微丝蚴血症和无微丝蚴血症的患者中均发现了与成虫抗原和可溶性微丝蚴抗原发生反应的抗体。仅在无微丝蚴血症的受试者中发现了与班氏吴策线虫微丝蚴表面抗原发生反应的抗体。仅在有微丝蚴血症和无微丝蚴血症的患者中用成虫抗原检测到了IgE抗体。IgG抗体的绝对水平显著高于IgE抗体。得出的结论是，测定与成虫抗原发生反应的血清抗体适用于感染的微丝蚴血症期和无微丝蚴血症期的诊断，而测定针对微丝蚴表面抗原的抗体适用于有明显临床疾病的患者。
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