de Bertoldi M, Griselli M, Giovannetti M, Barale R
Environ Mutagen. 1980;2(3):359-70. doi: 10.1002/em.2860020306.
Nine pesticides, Afugan, Atrazine, Benomyl, Captan, Daconil, Melthaumittel, Plantvax, Saprol, and Wepsin were tested for the induction of mitotic gene-conversion in two different eucaryotic microorganisms, Saccharomyces cerevisae and Aspergillus nidulans. In S cerevisiae the pesticides were also tested after mouse liver microsomal activation; in A nidulans all tests were performed using both resting and germinating conidia. Among the tested pesticides, only Captan revealed a consistent genetic activity, three times greater than that observed with the standard mutagen methylmethansulphonate. This genetic activity of Captan is suppressed after mammalian metabolic conversion. The use of germinating conidia in A nidulans for scoring the induction of mitotic gene-conversion did not give any further information on the activity of the tested pesticides.
对九种农药，即安百亩、莠去津、苯菌灵、克菌丹、百菌清、美草乐、植病灵、腐霉利和卫菌素，在两种不同的真核微生物酿酒酵母和构巢曲霉中进行了有丝分裂基因转换诱导测试。在酿酒酵母中，农药在经过小鼠肝脏微粒体激活后也进行了测试；在构巢曲霉中，所有测试均使用静止和萌发的分生孢子进行。在所测试的农药中，只有克菌丹显示出一致的遗传活性，比标准诱变剂甲磺酸甲酯观察到的活性大三倍。克菌丹的这种遗传活性在哺乳动物代谢转化后受到抑制。在构巢曲霉中使用萌发的分生孢子来计分有丝分裂基因转换的诱导，并未提供关于所测试农药活性的更多信息。
