乳过氧化物酶和硫氰酸盐可保护细菌免受过氧化氢的侵害。
Lactoperoxidase and thiocyanate protect bacteria from hydrogen peroxide.
作者信息
Adamson M, Carlsson J
出版信息
Infect Immun. 1982 Jan;35(1):20-4. doi: 10.1128/iai.35.1.20-24.1982.
Abstract
Lactoperoxidase and thiocyanate were shown to protect Escherichia coli and three oral streptococcal species from the bactericidal effect of hydrogen peroxide under aerobic conditions. Lactoperoxidase in the absence of thiocyanate was also protective for two of the bacterial species in a dilution medium but potentiated hydrogen peroxide toxicity for the other two under the same conditions. The products of the reaction between hydrogen peroxide and thiocyanate in the presence of lactoperoxidase were not bactericidal except in the case of E. coli, and then only under special conditions. The results demonstrate the effectiveness of lactoperoxidase and thiocyanate in protecting living cells from hydrogen peroxide toxicity. Although the effect on human cells was not examined in this study, extrapolation of these results to the cells of the oral mucosa would suggest an important protective role of lactoperoxidase and thiocyanate against the toxic effects of hydrogen peroxide in the oral cavity.
摘要
研究表明，在有氧条件下，乳过氧化物酶和硫氰酸盐可保护大肠杆菌和三种口腔链球菌免受过氧化氢的杀菌作用。在稀释培养基中，不存在硫氰酸盐时的乳过氧化物酶对其中两种细菌也具有保护作用，但在相同条件下，对另外两种细菌却会增强过氧化氢的毒性。在乳过氧化物酶存在的情况下，过氧化氢与硫氰酸盐反应的产物除对大肠杆菌外无杀菌作用，且仅在特殊条件下对大肠杆菌有杀菌作用。这些结果证明了乳过氧化物酶和硫氰酸盐在保护活细胞免受过氧化氢毒性方面的有效性。尽管本研究未检测其对人体细胞的影响，但将这些结果外推至口腔黏膜细胞表明，乳过氧化物酶和硫氰酸盐对口腔中过氧化氢的毒性作用具有重要的保护作用。
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