Welsh K I, Batchelor J R, Maynard A, Burgos H
J Exp Med. 1979 Sep 19;150(3):465-70. doi: 10.1084/jem.150.3.465.
Long surviving, passively enhanced (AS X AUG)F1 kidneys carried by AS recipients were retransplanted into (AS X WF)F1 second hosts. Acute graft rejection did not occur. Only one of six secondary recipients mounted a significant T-dependent IgG lymphocytotoxic antibody response. In all six, generation of cytotoxic T cells was markedly slower and depressed. These results are compatible with the hypothesis that kidney parenchyma, although carrying major histocompatibility complex specificity is able to induce T-independent but not T-dependent alloimmunity. A corollary is that passenger cells are responsible for exciting the T-dependent allimmune response normally observed after grafing. The practical difficulty of eliminating all T-dependent immunogenicity from (AS X AUG)F1 kidneys was emphasized by the observation that a 3-d residence in an intermediate AS recipient was insufficient time to prevent acute graft rejection after retransplantation.
长期存活、由同基因受体携带的被动增强型（AS×AUG）F1肾脏被再次移植到（AS×WF）F1二代宿主中。未发生急性移植物排斥反应。六个二代受体中只有一个产生了显著的T细胞依赖性IgG淋巴细胞毒性抗体反应。在所有六个受体中，细胞毒性T细胞的产生明显较慢且受到抑制。这些结果与以下假设相符：肾实质虽然携带主要组织相容性复合体特异性，但能够诱导非T细胞依赖性而非T细胞依赖性同种免疫。一个推论是过客细胞负责激发移植后通常观察到的T细胞依赖性同种免疫反应。观察结果强调了从（AS×AUG）F1肾脏中消除所有T细胞依赖性免疫原性的实际困难，即在中间同基因受体中停留3天的时间不足以防止再次移植后的急性移植物排斥反应。
