长期存活的、被动增强的肾同种异体移植未能激发T细胞依赖的同种免疫。I. （AS×AUG）F1代肾脏再次移植入二级AS受体。
Failure of long surviving, passively enhanced kidney allografts to provoke T-dependent alloimmunity. I. Retransplantation of (AS X AUG)F1 kidneys into secondary AS recipients.
作者信息
Batchelor J R, Welsh K I, Maynard A, Burgos H
出版信息
J Exp Med. 1979 Sep 19;150(3):455-64. doi: 10.1084/jem.150.3.455.
Abstract
Long survival of (AS X AUG)F1 rat kidney allografts in AS recipients was induced by passive enhancement with AS anti-AUG antiserum at the time of grafting. After 1-3 mo, the kidney allografts were transferred to second AS recipients, either naive or sensitized against AUG tissue. Naive second recipients did not reject the grafts acutely and failed to mount T-dependent immunity against AUG targets. When later challenged with spleen cells carrying the AUG haplotype, the naive second AS recipients showed strong IgM, IgG, and cytotoxic T-cell responses after grafting, and the kidneys were rapidly destroyed by immune rejection in all but one rat. It is concluded that long-surviving kidney allografts fail to activate helper T cells and induce in naive second recipients the same state of unresponsiveness observed in the first recipient.
摘要
在移植时用抗AUG抗血清进行被动增强，可诱导（AS×AUG）F1大鼠肾移植在AS受体中长期存活。1至3个月后，将肾移植转移至第二代AS受体，这些受体可以是未经致敏的，也可以是对AUG组织致敏的。未经致敏的第二代受体不会急性排斥移植肾，并且无法针对AUG靶标产生T细胞依赖性免疫。当后来用携带AUG单倍型的脾细胞进行攻击时，未经致敏的第二代AS受体在移植后表现出强烈的IgM、IgG和细胞毒性T细胞反应，除一只大鼠外，所有大鼠的肾脏均因免疫排斥反应而迅速被破坏。得出的结论是，长期存活的肾移植未能激活辅助性T细胞，也未能在未经致敏的第二代受体中诱导出与第一代受体相同的无反应状态。
相似文献
1
Failure of long surviving, passively enhanced kidney allografts to provoke T-dependent alloimmunity. I. Retransplantation of (AS X AUG)F1 kidneys into secondary AS recipients.长期存活的、被动增强的肾同种异体移植未能激发T细胞依赖的同种免疫。I. （AS×AUG）F1代肾脏再次移植入二级AS受体。
J Exp Med. 1979 Sep 19;150(3):455-64. doi: 10.1084/jem.150.3.455.
2
Failure of long surviving, passively enhanced kidney allografts to provoke T-dependent alloimmunity. II. Retransplantation of (AS X AUG)F1 kidneys from AS primary recipients into (AS X WF)F1 secondary hosts.长期存活的、被动增强的肾移植未能激发T细胞依赖的同种异体免疫。II. 将来自AS初次受体的（AS×AUG）F1肾再次移植到（AS×WF）F1二次受体中。
J Exp Med. 1979 Sep 19;150(3):465-70. doi: 10.1084/jem.150.3.465.
3
Mechanisms underlying continued survival of rat kidney allografts after a short period of chemical immunosuppression.短期化学免疫抑制后大鼠肾移植存活的潜在机制。
Transplantation. 1985 Aug;40(2):150-3. doi: 10.1097/00007890-198508000-00008.
4
W3/25+ T cells mediate the induction of immunologic unresponsiveness in enhanced rat recipients of cardiac allografts.W3/25+ T细胞介导心脏同种异体移植增强大鼠受体免疫无反应性的诱导。
J Immunol. 1987 Jun 1;138(11):3669-74.
5
Reduced immunogenicity of long-term, passively enhanced rat renal allografts and passive transfer of graft protection.长期被动增强的大鼠肾移植的免疫原性降低及移植保护的被动转移
Immunol Lett. 1986 Jan;12(1):19-24. doi: 10.1016/0165-2478(86)90075-1.
6
Immunogenicity of retransplanted rat kidney allografts. Effect of inducing chimerism in the first recipient and quantitative studies on immunosuppression of the second recipient.再移植大鼠肾同种异体移植物的免疫原性。在首位受者中诱导嵌合体的效果及对第二位受者免疫抑制的定量研究。
J Exp Med. 1982 Dec 1;156(6):1835-41. doi: 10.1084/jem.156.6.1835.
7
8
T cell requirements for the rejection of renal allografts bearing an isolated class I MHC disparity.T细胞对排斥具有单一I类主要组织相容性复合体差异的肾移植的要求。
J Exp Med. 1990 Dec 1;172(6):1547-57. doi: 10.1084/jem.172.6.1547.
9
引用本文的文献
1
Transplant Tolerance, Not Only Clonal Deletion.移植耐受，非仅克隆删除。
Front Immunol. 2022 Apr 21;13:810798. doi: 10.3389/fimmu.2022.810798. eCollection 2022.
2
Dendritic Cells: Versatile Players in Renal Transplantation.树突状细胞：肾移植中的多面手。
Front Immunol. 2021 May 19;12:654540. doi: 10.3389/fimmu.2021.654540. eCollection 2021.
3
The CD8 T-cell response during tolerance induction in liver transplantation.肝移植耐受诱导过程中的CD8 T细胞反应。
Clin Transl Immunology. 2016 Oct 14;5(10):e102. doi: 10.1038/cti.2016.53. eCollection 2016 Oct.
4
Immunotoxin Against a Donor MHC Class II Molecule Induces Indefinite Survival of Murine Kidney Allografts.针对供体MHC II类分子的免疫毒素可诱导小鼠肾移植长期存活
Am J Transplant. 2016 Apr;16(4):1129-38. doi: 10.1111/ajt.13584. Epub 2016 Jan 22.
5
Dendritic cells and innate immunity in kidney transplantation.肾移植中的树突状细胞与天然免疫
Kidney Int. 2015 Apr;87(4):712-8. doi: 10.1038/ki.2014.430. Epub 2015 Jan 28.
6
Cross-presentation by dendritic cells.树突状细胞的交叉呈递。
Nat Rev Immunol. 2012 Jul 13;12(8):557-69. doi: 10.1038/nri3254.
7
NK cell patrolling and elimination of donor-derived dendritic cells favor indirect alloreactivity.NK 细胞巡弋和清除供者来源的树突状细胞有利于间接同种异体反应性。
J Immunol. 2010 Mar 1;184(5):2329-36. doi: 10.4049/jimmunol.0902748. Epub 2010 Feb 5.
8
The larynx as an immunological organ: immunological architecture in the pig as a large animal model.作为免疫器官的喉：猪作为大型动物模型的免疫结构
Clin Exp Immunol. 2006 Jan;143(1):6-14. doi: 10.1111/j.1365-2249.2005.02950.x.
9
Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance.全器官移植后的细胞迁移与嵌合现象：移植物接受的基础
Hepatology. 1993 Jun;17(6):1127-52.
10
The dichotomous functions of passenger leukocytes in solid-organ transplantation.过客白细胞在实体器官移植中的双重功能
Adv Nephrol Necker Hosp. 1995;24:341-54.
本文引用的文献
1
Specific suppression of renal allograft rejection by treatment with antigen and antibody.通过抗原和抗体治疗特异性抑制肾移植排斥反应。
Transplant Proc. 1970 Dec;2(4):483-8.
2
Role of passenger leukocytes in the rejection of renal allografts.过客白细胞在同种异体肾移植排斥反应中的作用。
Transplant Proc. 1971 Mar;3(1):461-4.
3
Production of anti-H-2 antibodies in thymectomized mice.胸腺切除小鼠中抗H-2抗体的产生。
Eur J Immunol. 1974 Jan;4(1):41-4. doi: 10.1002/eji.1830040111.
4
Enhancement of renal allografts in rats and man.大鼠和人类同种异体肾移植的增强
Transplant Rev. 1972;13:115-41. doi: 10.1111/j.1600-065x.1972.tb00062.x.
5
Humoral and cell-mediated immunity in rats with enhanced kidney allografts.肾移植增强大鼠的体液免疫和细胞介导免疫。
Transplantation. 1974 Oct;18(4):328-35. doi: 10.1097/00007890-197410000-00005.
6
The alloantibody response to a strong transplantation antigen (Ag-B). Quantitative aspects and thymus dependence of the response.针对强移植抗原（Ag-B）的同种异体抗体反应。反应的定量方面及胸腺依赖性。
Transplantation. 1974 Apr;17(4):416-23. doi: 10.1097/00007890-197404000-00013.
7
The uptake of 125I-labeled rat alloantibody and its loss after combination with antigen.125I标记的大鼠同种抗体的摄取及其与抗原结合后的丢失
Transplantation. 1973 Dec;16(6):641-8. doi: 10.1097/00007890-197312000-00016.
8
Antibody turnover by enhanced rat kidneys.增强型大鼠肾脏的抗体周转
Transplant Proc. 1973 Mar;5(1):621-3.
9
The mechanism of specific immunosuppression of renal allograft rejection by donor strain blood.供体菌株血液对肾移植排斥反应的特异性免疫抑制机制。
Transplantation. 1972 Nov;14(5):634-40. doi: 10.1097/00007890-197211000-00016.
10
Immunological enhancement of rat kidney grafts.大鼠肾移植的免疫增强
Lancet. 1969 Nov 22;2(7630):1103-6. doi: 10.1016/s0140-6736(69)90705-3.
Zotero 插件