Batchelor J R, Welsh K I, Maynard A, Burgos H
J Exp Med. 1979 Sep 19;150(3):455-64. doi: 10.1084/jem.150.3.455.
Long survival of (AS X AUG)F1 rat kidney allografts in AS recipients was induced by passive enhancement with AS anti-AUG antiserum at the time of grafting. After 1-3 mo, the kidney allografts were transferred to second AS recipients, either naive or sensitized against AUG tissue. Naive second recipients did not reject the grafts acutely and failed to mount T-dependent immunity against AUG targets. When later challenged with spleen cells carrying the AUG haplotype, the naive second AS recipients showed strong IgM, IgG, and cytotoxic T-cell responses after grafting, and the kidneys were rapidly destroyed by immune rejection in all but one rat. It is concluded that long-surviving kidney allografts fail to activate helper T cells and induce in naive second recipients the same state of unresponsiveness observed in the first recipient.
在移植时用抗AUG抗血清进行被动增强，可诱导（AS×AUG）F1大鼠肾移植在AS受体中长期存活。1至3个月后，将肾移植转移至第二代AS受体，这些受体可以是未经致敏的，也可以是对AUG组织致敏的。未经致敏的第二代受体不会急性排斥移植肾，并且无法针对AUG靶标产生T细胞依赖性免疫。当后来用携带AUG单倍型的脾细胞进行攻击时，未经致敏的第二代AS受体在移植后表现出强烈的IgM、IgG和细胞毒性T细胞反应，除一只大鼠外，所有大鼠的肾脏均因免疫排斥反应而迅速被破坏。得出的结论是，长期存活的肾移植未能激活辅助性T细胞，也未能在未经致敏的第二代受体中诱导出与第一代受体相同的无反应状态。
