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[儿童慢性乙肝表面抗原阴性肝炎,采用免疫荧光法研究]

[Chronic HBsAg negative hepatitis in childhood, Stud using the immunofluorescence method].

作者信息

Calzia R, Ciravegna B, Navone C, Tolentino P

出版信息

Boll Ist Sieroter Milan. 1981 Jul 31;60(3):176-87.

PMID:7034745
Abstract

13 children with chronic HBsAg negative hepatitis were examined in this work with the I.F. method. Comparison can be made with a previous work on chronic HBsAg positive hepatitis. 8 of these patients were cases of ECP, 1 was a ECA-A and 4 were ECA-B. Research has been done to point out immunoglobulins and immunocomplexes in the liver and serum. On the whole, fluorescence was less both in liver and serum than fluorescence in chronic HBsAg positive hepatitis. Reasons of it can be: the absence of anti-virus B antibodies (HBcAb, delta-Ab, HBsAb), the relative lightness of our cases and, probably, a better answer of HBsAg negative hepatitis than of HBsAg positive one to immunodepressive treatment.

摘要

本研究采用免疫荧光法对13例慢性乙肝表面抗原(HBsAg)阴性肝炎患儿进行了检查。可与之前关于慢性HBsAg阳性肝炎的研究进行比较。其中8例患者为自身免疫性慢性活动性肝炎(ECP),1例为自身免疫性慢性迁延性肝炎伴自身抗体(ECA - A),4例为自身免疫性慢性迁延性肝炎(ECA - B)。已对肝脏和血清中的免疫球蛋白及免疫复合物进行了研究。总体而言,肝脏和血清中的荧光均低于慢性HBsAg阳性肝炎中的荧光。其原因可能为:缺乏抗病毒B抗体(乙肝核心抗体、δ抗体、乙肝表面抗体),我们所研究病例病情相对较轻,以及HBsAg阴性肝炎可能比HBsAg阳性肝炎对免疫抑制治疗反应更好。

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