Sundnes K O, Vaagenes P, Skretting P, Lind B, Edstróm H H
Br J Anaesth. 1982 Jan;54(1):69-74. doi: 10.1093/bja/54.1.69.
The effects of 0.5% bupivacaine 1.5, 2 and 3 ml in 8% glucose was compared in a double-blind study involving 30 patients undergoing spinal analgesia. The time to the onset of maximum segmental spread of analgesia was approximately 15 min for all three volumes. Cephalad spread of analgesia was related to the volume used: 1.5 ml reached T10, 2 ml T8 and 3 ml T7. The duration of analgesia increased with increasing volume, 3 ml producing analgesia in T8-T12 for 1.5-2 h, and in the lumbar region for 2.5-3 h. Increasing the volume increased the extent of motor blockade and speeded up its onset. Significant decreases in arterial pressure were observed in the 2- and 3-ml groups. The changes in heart rate were moderate and not correlated with the amount of drug. Spinal headache occurred in two patients.
在一项双盲研究中，对30例接受脊髓镇痛的患者比较了0.5%布比卡因1.5、2和3毫升加入8%葡萄糖后的效果。所有三个剂量组镇痛最大节段扩散开始时间约为15分钟。镇痛的头端扩散与所用剂量有关：1.5毫升达到T10，2毫升达到T8，3毫升达到T7。镇痛持续时间随剂量增加而延长，3毫升在T8-T12产生1.5-2小时的镇痛，在腰部区域产生2.5-3小时的镇痛。增加剂量会增加运动阻滞的程度并加快其起效。在2毫升和3毫升组中观察到动脉压显著下降。心率变化适中，与药物用量无关。两名患者出现了脊髓性头痛。
