Intravascular coagulation in mice by the compact-colony-forming active substance (CCFAS) extracted from a strain of Staphylococcus aureus.

The compact-colony-forming active substance (CCFAS) extracted from a Staphylococcus aureus strain was capable of killing mice only when Staph. aureus, Staph. epidermidis or Escherichia coli was injected i.v. before the injection of CCFAS. In the mice killed 30 min after treatment with heat-killed Staph. aureus and CCFAS, remarkable congestion of the lung and thrombus-like lesions in the kidney were observed. In the mice killed 6 h after injection with CCFAS and living Staph. aureus congestion and inflammatory-cell filtration were found in the liver, especially within the Glisson's capsule. However, when mice were killed 30 days after treatment with CCFAS and Staph. aureus, fibrin and hyalin thrombi were observed most frequently in the renal glomeruli but also in the liver and lung.