DeVoe I W, Gilka F
J Med Microbiol. 1976 Nov;9(4):451-8. doi: 10.1099/00222615-9-4-451.
Leucocyte-egested material was harvested after the quantitative in-vitro phagocytosis of Neisseria meningitidis by rabbit or mouse polymorphonuclear leucocytes. The egested material was injected subcutaneously into rabbits and followed 24 h later with an intravenous injection of what would by itself have been a non-lethal quantity of meningococcal endotoxin, or with an equivalent dose of endotoxin in the form of meningococcal cell-wall blebs. Of 32 rabbits treated in this manner, 12 developed disseminated intravascular coagulation and six of these 12 had renal cortical necrosis. The remainder exhibited less severe lesions resembling those of endotoxaemia. Rabbits were not sensitised to meningococcal endotoxin when materials egested from leucocytes containing Staphylococcus epidermidis were used. A description of the pathological findings in the rabbits is presented.
在兔或小鼠多形核白细胞对脑膜炎奈瑟菌进行定量体外吞噬作用后，收集白细胞排出的物质。将排出的物质皮下注射到兔体内，24小时后静脉注射本身剂量不会致死的脑膜炎球菌内毒素，或以脑膜炎球菌细胞壁泡的形式注射等量的内毒素。以这种方式处理的32只兔中，12只发生了弥散性血管内凝血，这12只中的6只出现了肾皮质坏死。其余的表现出较轻的类似内毒素血症的病变。当使用从含有表皮葡萄球菌的白细胞中排出的物质时，兔对脑膜炎球菌内毒素不敏感。本文描述了兔的病理发现。
