Mallinson H, Arya O P, Goddard A D
Br J Vener Dis. 1982 Feb;58(1):36-9. doi: 10.1136/sti.58.1.36.
Chlamydia trachomatis inclusion counts on inoculated McCoy cell coverslips were used as an index of the degree of infection of the cervix in women and of the urethra in men with urethritis. High inclusion counts were obtained significantly more often from men than from women, from women with cervical ectopy, and from women who had had recent sexual intercourse. Low inclusion counts were significantly more common in men with a past history of gonococcal urethritis. Higher chlamydial isolation rates in women with gonorrhoea and in women taking the contraceptive pill could not be attributed to a greater degree of infection, since inclusion counts were not raised in these patients. There was evidence that strains of C trachomatis might vary in their ability to establish themselves in the genital tract because high counts in men with NGU were associated with high counts in their female consorts and the levels of counts in men were associated with the frequency of chlamydial isolation from their female consorts. The relatively simple technique of inclusion counts in cultures for chlamydia from the genital tract may yield valuable information about the behaviour of different strains of C trachomatis in causing pathological changes, in the transmission of infection between individuals, and in the response to specific chemotherapy.
接种 McCoy 细胞盖玻片上沙眼衣原体包涵体计数被用作女性宫颈和男性尿道炎患者尿道感染程度的指标。男性获得高包涵体计数的频率显著高于女性、宫颈异位的女性以及近期有过性行为的女性。既往有淋菌性尿道炎病史的男性中，低包涵体计数更为常见。淋病女性患者和服用避孕药的女性中较高的衣原体分离率不能归因于感染程度更高，因为这些患者的包涵体计数并未升高。有证据表明，沙眼衣原体菌株在生殖道中定植的能力可能不同，因为非淋菌性尿道炎男性患者的高计数与他们女性性伴的高计数相关，且男性的计数水平与从他们女性性伴中分离出衣原体的频率相关。从生殖道培养物中进行衣原体包涵体计数这一相对简单的技术，可能会产生有关不同沙眼衣原体菌株在引起病理变化、个体间感染传播以及对特定化疗反应方面行为的有价值信息。
