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抗线粒体抗体的异质性:线粒体基质和外膜中抗原的证据(作者译)

[Heterogeneity of antimitochondrial antibodies: evidence for antigens in the mitochondrial matrix and outer membranes (author's transl)].

作者信息

Storch W, Emmrich J, Blatz R, Dargel R

出版信息

Dtsch Z Verdau Stoffwechselkr. 1981;41(5):241-8.

PMID:7035135
Abstract

Human sera of patients with liver diseases (n = 7) and with systemic lupus erythematosus (n = 1) containing different antimitochondrial and other antibodies detected by immunofluorescence were reexamined after absorption with various subcellular mitochondrial fractions (whole extract, enriched inner and outer membranes, matrix, respectively). The findings were compared with those of the complement binding tests. The results suggest, that the antimitochondrial antibodies are directed against different antigens localized in the inner as well as in the outer membranes, in the matrix, and in other compartments of mitochondria, especially antibodies of type 4, 5, 7 and 8.

摘要

对患有肝脏疾病(n = 7)和系统性红斑狼疮(n = 1)的患者的人血清进行了重新检测,这些血清通过免疫荧光检测含有不同的抗线粒体抗体和其他抗体,在分别用各种亚细胞线粒体组分(全提取物、富集的内膜和外膜、基质)吸收后进行检测。将结果与补体结合试验的结果进行比较。结果表明,抗线粒体抗体针对的是位于线粒体内膜、外膜、基质以及线粒体其他区室中的不同抗原,尤其是4型、5型、7型和8型抗体。

相似文献

1
[Heterogeneity of antimitochondrial antibodies: evidence for antigens in the mitochondrial matrix and outer membranes (author's transl)].抗线粒体抗体的异质性:线粒体基质和外膜中抗原的证据(作者译)
Dtsch Z Verdau Stoffwechselkr. 1981;41(5):241-8.
2
[Detection of antimitochondrial antibodies by immunodiffusion, ELISA and immunofluorescence methods].[采用免疫扩散法、酶联免疫吸附测定法及免疫荧光法检测抗线粒体抗体]
Orv Hetil. 1990 Jan 14;131(2):67-70, 73.
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