Labro M T, Andrieu M C, Weber M, Homberg J C
Clin Exp Immunol. 1978 Mar;31(3):357-66.
About 0.1% of the sera in human pathology produce a peculiar, cytoplasmic, non-organ- and non-species-specific fluorescence. This may easily be differentiated from the already described anti-organelle antibodies and, more particularly, from the mitochondrial antibodies of primary biliary cirrhosis. Should rat tissues be used in the immunofluorescence test, fluorescence predominates over the first two portions of the renal proximal tubules (P1 and P2) and the mucous neck cells of the stomach. This pattern may be atrributed to mitochondria, and in particular to their inner membranes by fluorescent staining of the ellipsoid region of the rods and cones of the eyes, and by absorption with purified organelles. To distinguish this antibody from the already described mitochondrial antibodies, this one will be called mitochondrial antibody number 5 (M5). The seven carriers of this antibody suffer from systemic lupus erythematosus or autoimmune haemolytic anaemia. In these cases no diseases of the liver were observed, contrary to other classical mitochondrial antibodies.
在人类病理学中，约0.1%的血清会产生一种特殊的、细胞质的、非器官特异性和非物种特异性的荧光。这很容易与已描述的抗细胞器抗体区分开来，尤其是与原发性胆汁性肝硬化的线粒体抗体区分开来。如果在免疫荧光试验中使用大鼠组织，荧光在肾近端小管的前两部分（P1和P2）以及胃的黏液颈细胞中占主导。这种模式可能归因于线粒体，特别是通过对眼视杆和视锥细胞的椭圆形区域进行荧光染色以及用纯化的细胞器进行吸收，归因于线粒体内膜。为了将这种抗体与已描述的线粒体抗体区分开来，这种抗体将被称为线粒体抗体5（M5）。该抗体携带者中有7人患有系统性红斑狼疮或自身免疫性溶血性贫血。与其他经典线粒体抗体不同，在这些病例中未观察到肝脏疾病。
