Whong W Z, Sorenson W G, Elliott J A, Stewart J, Simpson J, Piacitelli L, McCawley M, Ong T
Mutat Res. 1982 Jan;103(1):5-12. doi: 10.1016/0165-7992(82)90078-1.
3 oil-shale ash samples were extracted with solvents and analyzed for mutagenicity with a number of tests systems. In Salmonella typhimurium, the ash extracts were highly mutagenic with the Ames his reversion and the ara-resistant systems. Mutation induction by the ash in Salmonella was independent of metabolic activation and was of the frameshift type. These ash extracts showed a substantial killing effect, but failed to induced ad-3 reversion in Neurospora crassa, gene conversion and mitotic crossing-over in Saccharomyces cerevisiae and TGr mutation in cultured CHO cells.
用溶剂提取了3个油页岩灰样品，并使用多种测试系统分析其致突变性。在鼠伤寒沙门氏菌中，灰提取物在艾姆斯组氨酸回复突变和抗阿拉伯糖系统中具有高度致突变性。沙门氏菌中灰诱导的突变与代谢激活无关，属于移码型。这些灰提取物显示出显著的杀伤作用，但未能在粗糙脉孢菌中诱导ad-3回复突变、在酿酒酵母中诱导基因转换和有丝分裂交换以及在培养的中国仓鼠卵巢细胞中诱导TGr突变。
