Morling N, Hellesen C, Jakobsen B K, Platz P, Ryder L P, Svejgaard A, Thomsen M
Tissue Antigens. 1981;17(4):433-41. doi: 10.1111/j.1399-0039.1981.tb00725.x.
A total of 48 patients with juvenile chronic arthritis (JCA) were typed for HLA-A, -B, -C, -D and -DR antigens and 36 patients were also typed for HLA-D/DR associated "DR"-antigens with the primed lymphocyte typing technique. In the total group of patients, we found increased frequencies of HLA-B27, HLA-Dw/DP5 and HLA-Dw/DP8, and decreased frequencies of HLA-Dw/-DR/DP2. The increased frequencies of HLA-Dw/DP8 and the decreased frequencies of HLA-Dw/-DR/DP2 were primarily found among patients with persistent pauciarticular arthritis. The frequencies of HLA-Dw/-DR/DP4 were increased in patients with polyarticular arthritis. The frequencies of HLA-B27 and -Dw/DP5 were increased in both pauciarticular and polyarticular arthritis. The results indicate (i) that genetic factors controlled by HLA confer susceptibility and/or resistance to JCA, and (ii) that the clinical subdivision of JCA into pauciarticular and polyarticular JCA can be supported by the presence of different genetic markers (HLA-antigens) in the two groups of JCA-patients. If these data can be confirmed HLA-D, -DR or DP typing may be of value in the prognostic evaluation of patients with pauciarticular onset JCA.
对48例青少年慢性关节炎（JCA）患者进行了HLA - A、- B、- C、- D和 - DR抗原分型，并用致敏淋巴细胞分型技术对36例患者进行了HLA - D/DR相关“DR”抗原分型。在全部患者组中，我们发现HLA - B27、HLA - Dw/DP5和HLA - Dw/DP8频率增加，而HLA - Dw/- DR/DP2频率降低。HLA - Dw/DP8频率增加和HLA - Dw/- DR/DP2频率降低主要见于持续性少关节型关节炎患者。多关节型关节炎患者中HLA - Dw/- DR/DP4频率增加。少关节型和多关节型关节炎患者中HLA - B27和 - Dw/DP5频率均增加。结果表明：（i）由HLA控制的遗传因素赋予了对JCA的易感性和/或抗性；（ii）JCA分为少关节型和多关节型JCA的临床分类可由两组JCA患者中存在不同的遗传标记（HLA抗原）得到支持。如果这些数据能够得到证实，HLA - D、- DR或DP分型可能对少关节起病JCA患者的预后评估有价值。
