Malleson P N, Fung M Y, Petty R E, Mackinnon M J, Schroeder M L
Department of Pediatrics, University of British Columbia, Canada.
Ann Rheum Dis. 1992 Dec;51(12):1301-6. doi: 10.1136/ard.51.12.1301.
Studies have shown the presence of either antibodies to histone or anticardiolipin antibodies in some forms of childhood chronic arthritis. The relation between these autoantibodies has not been previously reported, however, and the immunogenetics of their association with childhood arthritis has not been studied.
The interrelation of fluorescent antinuclear antibodies, antibodies to histone, and anticardiolipin antibodies and their associations with histocompatibility antigens (HLA) were studied in 114 children with chronic arthritis (45 children with pauciarticular onset juvenile chronic arthritis (JCA), 22 with polyarticular onset JCA, 13 with systemic onset JCA, and 34 with juvenile psoriatic arthritis (JPsA). Antibodies to histone and anticardiolipin antibodies were determined in 108 children. HLA antigens (A, B, C, and DR) were studied in the 83 white children.
Antibodies to histone occurred in 0% (systemic onset JCA) to 42% (uveitis negative, pauciarticular onset JCA), and anticardiolipin antibodies in 26% (JPsA) to 55% (polyarticular onset JCA) of patients. Only 12 patients (11%) had both antibodies to histone and anticardiolipin antibodies. Neither antibodies to histone nor anticardiolipin antibodies associated with the type of arthritis. Neither of these antibodies alone associated with uveitis. Antibodies to histone were associated with HLA-A2, probably reflecting the known association of HLA-A2 with pauciarticular onset JCA. There was no other HLA association. Fluorescent antinuclear antibodies occurred most often in patients with uveitis; however, the occurrence of fluorescent antinuclear antibodies in patients with pauciarticular onset JCA (the group most at risk for uveitis) was not significantly greater in children with uveitis than in those without uveitis (100 and 88% respectively).
Although antibodies to histone and anticardiolipin antibodies often occur in serum samples from patients with JCA and JPsA, they rarely occur together. Their presence does not associate with uveitis. This study did not show any strong evidence that production of either antibodies to histone or anticardiolipin antibodies in patients with JCA or JPsA is under the control of the histocompatibility locus.
研究表明，在某些形式的儿童慢性关节炎中存在组蛋白抗体或抗心磷脂抗体。然而，这些自身抗体之间的关系此前尚未见报道，而且它们与儿童关节炎关联的免疫遗传学也未得到研究。
对114例慢性关节炎患儿（45例少关节起病的幼年慢性关节炎（JCA）、22例多关节起病的JCA、13例全身起病的JCA以及34例幼年银屑病关节炎（JPsA））进行了荧光抗核抗体、组蛋白抗体和抗心磷脂抗体的相互关系及其与组织相容性抗原（HLA）关联的研究。对108例患儿检测了组蛋白抗体和抗心磷脂抗体。对83例白人患儿研究了HLA抗原（A、B、C和DR）。
组蛋白抗体在0%（全身起病的JCA）至42%（葡萄膜炎阴性、少关节起病的JCA）的患者中出现，抗心磷脂抗体在26%（JPsA）至55%（多关节起病的JCA）的患者中出现。只有12例患者（11%）同时具有组蛋白抗体和抗心磷脂抗体。组蛋白抗体和抗心磷脂抗体均与关节炎类型无关。这两种抗体单独出现时均与葡萄膜炎无关。组蛋白抗体与HLA - A2相关，这可能反映了已知的HLA - A2与少关节起病的JCA的关联。没有其他HLA关联。荧光抗核抗体最常出现在葡萄膜炎患者中；然而，在少关节起病的JCA患者（葡萄膜炎风险最高的组）中，有葡萄膜炎的儿童荧光抗核抗体的出现率并不显著高于无葡萄膜炎的儿童（分别为100%和88%）。
虽然组蛋白抗体和抗心磷脂抗体在JCA和JPsA患者的血清样本中经常出现，但它们很少同时出现。它们的存在与葡萄膜炎无关。本研究未显示任何有力证据表明JCA或JPsA患者中组蛋白抗体或抗心磷脂抗体的产生受组织相容性位点的控制。
