儿童IgM类风湿因子阳性关节炎的HLA研究
HLA studies in IgM rheumatoid-factor-positive arthritis of childhood.
作者信息
Clemens L E, Albert E, Ansell B M
出版信息
Ann Rheum Dis. 1983 Aug;42(4):431-4. doi: 10.1136/ard.42.4.431.
Abstract
The clinical course of children with IgM rheumatoid-factor-positive chronic arthritis closely resembles that of seropositive rheumatoid disease in adults. The frequency of HLA DR4 is known to be increased in adults with seropositive rheumatoid arthritis, but the first major report on childhood arthritis did not suggest a correlation, though only 8 seropositive cases were included. Fifty-two children with polyarthritis beginning before the age of 16 who persistently carried IgM rheumatoid factor were studied. HLA DR4 was present in 60% of these children but was found in only 29% of 93 patients with seronegative juvenile arthritis and 27% of a normal adult population. These results suggest immunogenetic similarities in patients with seropositive arthritis irrespective of age of onset.
摘要
IgM类风湿因子阳性的儿童慢性关节炎的临床病程与成人血清阳性类风湿疾病极为相似。已知成人血清阳性类风湿关节炎患者中HLA DR4的频率增加，但关于儿童关节炎的首份主要报告并未表明存在相关性，尽管仅纳入了8例血清阳性病例。对52例16岁前起病且持续携带IgM类风湿因子的多关节炎患儿进行了研究。这些患儿中有60%存在HLA DR4，但在93例血清阴性青少年关节炎患者中仅29%发现该因子，在正常成人人群中为27%。这些结果表明，血清阳性关节炎患者无论发病年龄如何，都存在免疫遗传学相似性。
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