• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

一种用于烧伤创面切除与移植的两阶段技术。

A two-stage technique for excision and grafting of burn wounds.

作者信息

Warden G D, Saffle J R, Kravitz M

出版信息

J Trauma. 1982 Feb;22(2):98-103. doi: 10.1097/00005373-198202000-00004.

DOI:10.1097/00005373-198202000-00004
PMID:7038136
Abstract

While the technique of early excision and grafting has many advantages in the treatment of thermal injuries, it is not without significant complications. Hemorrhage accompanying burn wound excision can be deceptively great, as can the metabolic stress of large surgical procedures performed in the postburn period. In an effort to minimize these complications, we have developed a two-stage technique for excision and grafting of burn wounds. This technique employs layered excision of eschar, followed by an overnight stabilization period for restoration of normal body temperature and blood volume. Continuous soaking of excised areas promotes hemostasis, and insures a viable base for autografting performed on the following day. During 1978-1979, 117 burn patients underwent 137 two-stage excision and grafting procedures. Mean graft size was 1,988 cm2. Eighty-two per cent of the patients had all necessary grafting performed in a single two-stage operation, including grafts as large as 5,700 cm2. No graft loss occurred as a result of graft hematoma formation. Mean blood loss calculated for each two-stage operation was 2,627 cc, one third of which resulted from the harvesting of autografts. Temperature decrease during surgery was also great, with significant hypothermia occurring in 51% of procedures exceeding 2 hours in length. We conclude that performing excision and grafting in two stages limits hemorrhage and heat loss from each individual surgery, thereby permitting the performance of larger procedures. Nonetheless, continued awareness of the magnitude of these complications remains an essential of successful excisional therapy.

摘要

虽然早期切除与植皮技术在治疗热烧伤方面有诸多优势,但并非没有严重并发症。烧伤创面切除时伴随的出血可能看似量少实则量大,烧伤后进行大型外科手术时的代谢应激情况同样如此。为尽量减少这些并发症,我们研发了一种烧伤创面切除与植皮的两阶段技术。该技术采用分层切除焦痂,随后有一个过夜稳定期以恢复正常体温和血容量。对切除区域持续浸泡可促进止血,并确保次日进行自体植皮时有一个存活的基底。在1978 - 1979年期间,117例烧伤患者接受了137次两阶段切除与植皮手术。平均植皮面积为1988平方厘米。82%的患者在单次两阶段手术中完成了所有必要的植皮,包括面积达5700平方厘米的植皮。未因植皮血肿形成而出现植皮丢失情况。每次两阶段手术计算出的平均失血量为2627立方厘米,其中三分之一是由于采集自体皮所致。手术期间体温下降也很明显,51%时长超过2小时的手术出现了显著的体温过低情况。我们得出结论,分两阶段进行切除与植皮可限制每次个体手术中的出血和热量损失,从而允许进行更大规模的手术。尽管如此,持续意识到这些并发症的严重程度仍是成功切除治疗的关键要素。

相似文献

1
A two-stage technique for excision and grafting of burn wounds.一种用于烧伤创面切除与移植的两阶段技术。
J Trauma. 1982 Feb;22(2):98-103. doi: 10.1097/00005373-198202000-00004.
2
[Efficacies of treating large area third-degree burns by tangential excision and skin grafting for subcutaneous tissue wounds].[削痂植皮治疗大面积三度烧伤皮下组织创面的疗效]
Zhonghua Yi Xue Za Zhi. 2014 Dec 2;94(44):3492-6.
3
[Effects of minimally invasive tangential excision in treating deep partial-thickness burn wounds on trunk and limbs in pediatric patients in the early stage post burn].[微创切线切除治疗小儿烧伤后早期躯干及四肢深Ⅱ度烧伤创面的效果]
Zhonghua Shao Shang Za Zhi. 2018 Oct 20;34(10):714-718. doi: 10.3760/cma.j.issn.1009-2587.2018.10.012.
4
[Effects of unified surgical scheme for wounds on the treatment outcome of patients with extensive deep burn].创面统一手术方案对大面积深度烧伤患者治疗效果的影响
Zhonghua Shao Shang Za Zhi. 2015 Aug;31(4):254-8.
5
Early surgical excision and grafting of burns including tangential excision.烧伤的早期手术切除与植皮,包括削痂术。
Prog Pediatr Surg. 1981;14:133-49.
6
Antecedent thermal injury worsens split-thickness skin graft quality: A clinically relevant porcine model of full-thickness burn, excision and grafting.既往热损伤会降低中厚皮片移植质量:全层烧伤、切除及移植的临床相关猪模型
Burns. 2017 Feb;43(1):223-231. doi: 10.1016/j.burns.2016.08.006. Epub 2016 Sep 3.
7
Delayed primary closure of the burn wounds.烧伤创面的延迟一期闭合。
Burns. 2004 Mar;30(2):169-75. doi: 10.1016/j.burns.2003.09.028.
8
[Experience of immediate burn wound excision and grafting for patients with extensive burns].[大面积烧伤患者烧伤创面早期切痂植皮的经验]
Nihon Geka Gakkai Zasshi. 2005 Dec;106(12):745-9.
9
The effect of topical epinephrine hydrochloride in saline on blood loss following tangential excision of burn wounds.盐水中局部应用盐酸肾上腺素对烧伤创面切痂术后失血的影响。
Plast Reconstr Surg. 1983 Dec;72(6):830-6. doi: 10.1097/00006534-198312000-00016.
10
Prospective study of burn wound excision of the hands.手部烧伤创面切除的前瞻性研究。
J Trauma. 1983 Jun;23(6):510-7. doi: 10.1097/00005373-198306000-00012.

引用本文的文献

1
Topical Tranexamic Acid on Donor Wounds in Burn Patients: A Randomized Placebo-controlled Trial.外用氨甲环酸治疗烧伤患者供皮区创面:一项随机安慰剂对照试验
Plast Reconstr Surg Glob Open. 2024 Aug 22;12(8):e6074. doi: 10.1097/GOX.0000000000006074. eCollection 2024 Aug.
2
Quality management overview for the production of a tissue-engineered human skin substitute in Malaysia.马来西亚组织工程人皮替代物生产的质量管理概述。
Stem Cell Res Ther. 2023 Oct 20;14(1):298. doi: 10.1186/s13287-023-03536-9.
3
Current understanding of thermo(dys)regulation in severe burn injury and the pathophysiological influence of hypermetabolism, adrenergic stress and hypothalamic regulation-a systematic review.
严重烧伤中热(调节异常)调节的当前认识以及高代谢、肾上腺素能应激和下丘脑调节的病理生理影响——一项系统综述
Burns Trauma. 2022 Sep 23;10:tkac031. doi: 10.1093/burnst/tkac031. eCollection 2022.
4
Down-Regulation of MHC Class I Expression in Human Keratinocytes Using Viral Vectors Containing Gene of Human Cytomegalovirus and Cultivation on Bovine Collagen-Elastin Matrix (Matriderm): Potential Approach for an Immune-Privileged Skin Substitute.利用含有人类巨细胞病毒基因的病毒载体下调人角质形成细胞中 MHC Ⅰ类表达并在牛胶原弹性蛋白基质(Matriderm)上培养:免疫特惠性皮肤替代物的潜在方法。
Int J Mol Sci. 2019 Apr 26;20(9):2056. doi: 10.3390/ijms20092056.
5
Tissue engineering of skin and regenerative medicine for wound care.用于伤口护理的皮肤组织工程与再生医学
Burns Trauma. 2018 Jan 24;6:4. doi: 10.1186/s41038-017-0103-y. eCollection 2018.
6
The impact of operative time and hypothermia in acute burn surgery.急性烧伤手术中手术时间及体温过低的影响
Burns. 2017 Dec;43(8):1673-1681. doi: 10.1016/j.burns.2017.10.001. Epub 2017 Oct 28.
7
Synthesis and characterization of collagen/PLGA biodegradable skin scaffold fibers.胶原蛋白/聚乳酸-羟基乙酸共聚物可生物降解皮肤支架纤维的合成与表征
Regen Biomater. 2017 Oct;4(5):309-314. doi: 10.1093/rb/rbx026. Epub 2017 Sep 25.
8
Randomized, Paired-Site Comparison of Autologous Engineered Skin Substitutes and Split-Thickness Skin Graft for Closure of Extensive, Full-Thickness Burns.自体工程皮肤替代物与中厚皮片用于大面积全层烧伤闭合的随机配对部位比较
J Burn Care Res. 2017 Mar/Apr;38(2):61-70. doi: 10.1097/BCR.0000000000000401.
9
Morphogenesis and Biomechanics of Engineered Skin Cultured Under Uniaxial Strain.单轴应变下培养的工程皮肤的形态发生与生物力学
Adv Wound Care (New Rochelle). 2012 Apr;1(2):69-74. doi: 10.1089/wound.2011.0345.
10
Novel biodegradable sandwich-structured nanofibrous drug-eluting membranes for repair of infected wounds: an in vitro and in vivo study.新型可生物降解夹层结构纳米纤维载药膜修复感染性创面:体外与体内研究。
Int J Nanomedicine. 2012;7:763-71. doi: 10.2147/IJN.S29119. Epub 2012 Feb 13.