口服噻吗洛尔联合肾上腺素的剂量反应。
Dose response of oral timolol combined with adrenaline.
作者信息
Ohrström A
出版信息
Br J Ophthalmol. 1982 Apr;66(4):242-6. doi: 10.1136/bjo.66.4.242.
Abstract
Oral timolol, a beta-adrenergic receptor blocker, was given in 5 different doses from 5 mg to 30 mg a day to 12 healthy volunteers in a double-blind cross-over trial. Adrenaline was instilled into one eye in each subject. Recording of intraocular pressure during the trial suggested the presence of a dose-response relationship between the dose of timolol and the decrease of intraocular pressure. An analysis of the interaction of timolol and adrenaline showed that the adrenaline effect diminished linearly with increasing timolol dose, which finally made the combination less effective than timolol alone.
摘要
在一项双盲交叉试验中，给12名健康志愿者口服不同剂量（5毫克至30毫克/天）的β-肾上腺素能受体阻滞剂噻吗洛尔。给每个受试者的一只眼睛滴入肾上腺素。试验期间对眼压的记录表明，噻吗洛尔剂量与眼压降低之间存在剂量反应关系。噻吗洛尔与肾上腺素相互作用的分析表明，随着噻吗洛尔剂量增加，肾上腺素的作用呈线性减弱，最终使得联合用药的效果不如单独使用噻吗洛尔。
相似文献
1
Dose response of oral timolol combined with adrenaline.口服噻吗洛尔联合肾上腺素的剂量反应。
Br J Ophthalmol. 1982 Apr;66(4):242-6. doi: 10.1136/bjo.66.4.242.
2
Dose-related interaction between timolol and adrenaline.噻吗洛尔与肾上腺素之间的剂量相关相互作用。
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1981;216(1):55-9. doi: 10.1007/BF00407777.
3
The effect of 1.5% timolol maleate on intraocular pressure.
Acta Ophthalmol (Copenh). 1978 Feb;56(1):6-10. doi: 10.1111/j.1755-3768.1978.tb00462.x.
4
Acute effect of epinephrine on aqueous humor formation in the timolol-treated normal eye as measured by fluorophotometry.通过荧光光度法测量肾上腺素对噻吗洛尔治疗的正常眼房水生成的急性作用。
Invest Ophthalmol Vis Sci. 1980 Apr;19(4):420-3.
5
Timolol and epinephrine: a clinical study of ocular interactions.
Arch Ophthalmol. 1980 Mar;98(3):484-6. doi: 10.1001/archopht.1980.01020030480008.
6
A comparison of the efficacy of betaxolol and timolol in ocular hypertension with or without adrenaline.倍他洛尔与噻吗洛尔在有或无肾上腺素情况下治疗高眼压症疗效的比较。
Aust N Z J Ophthalmol. 1989 May;17(2):173-7. doi: 10.1111/j.1442-9071.1989.tb00509.x.
7
Effect of timolol eye drops in subjects receiving systemic propranolol therapy.
Can J Ophthalmol. 1983 Feb;18(1):18-21.
8
Timolol maleate: efficacy and safety.
Arch Ophthalmol. 1979 Apr;97(4):656-8. doi: 10.1001/archopht.1979.01020010312004.
9
Effect of ophthalmic administration of S-596 (Arotinolol) on intraocular pressure and haemodynamics in health volunteers: comparison with timolol.健康志愿者眼部给药S-596（阿罗洛尔）对眼压和血流动力学的影响：与噻吗洛尔的比较。
Eur J Clin Pharmacol. 1985;28(4):391-6. doi: 10.1007/BF00544356.
10
Study of the additive effect of timolol and epinephrine in lowering intraocular pressure.噻吗洛尔与肾上腺素降眼压相加作用的研究
Br J Ophthalmol. 1981 Sep;65(9):596-602. doi: 10.1136/bjo.65.9.596.
引用本文的文献
1
Ocular beta-blockers in glaucoma management. Clinical pharmacological aspects.青光眼治疗中的眼部β受体阻滞剂。临床药理学方面。
Drugs Aging. 1992 May-Jun;2(3):208-21. doi: 10.2165/00002512-199202030-00005.
本文引用的文献
1
Timolol and epinephrine: a clinical study of ocular interactions.
Arch Ophthalmol. 1980 Mar;98(3):484-6. doi: 10.1001/archopht.1980.01020030480008.
2
Acute effect of epinephrine on aqueous humor formation in the timolol-treated normal eye as measured by fluorophotometry.通过荧光光度法测量肾上腺素对噻吗洛尔治疗的正常眼房水生成的急性作用。
Invest Ophthalmol Vis Sci. 1980 Apr;19(4):420-3.
3
Immediate effect of epinephrine on aqueous formation in the normal human eye as measured by fluorophotometry.通过荧光光度法测量肾上腺素对正常人类眼睛房水生成的即时效应。
Invest Ophthalmol Vis Sci. 1980 Mar;19(3):256-66.
4
Timolol and epinephrine in primary open angle glaucoma. Transient additive effect.
Arch Ophthalmol. 1981 Jan;99(1):91-5. doi: 10.1001/archopht.1981.03930010093010.
5
Interaction of timolol and adrenaline.噻吗洛尔与肾上腺素的相互作用。
Br J Ophthalmol. 1981 Jan;65(1):53-5. doi: 10.1136/bjo.65.1.53.
6
Dose-related interaction between timolol and adrenaline.噻吗洛尔与肾上腺素之间的剂量相关相互作用。
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1981;216(1):55-9. doi: 10.1007/BF00407777.
7
[The effect of timolol and dipivalyl-epinephrine in the treatment of the elevated intraocular pressure (author's transl)].噻吗洛尔与二特戊酰肾上腺素治疗眼压升高的效果（作者译）
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1980;213(4):273-81. doi: 10.1007/BF00417550.
8
Clinical experience with propranolol in the treatment of glaucoma.
Acta Ophthalmol (Copenh). 1973;51(5):639-44. doi: 10.1111/j.1755-3768.1973.tb08256.x.
9
Treatment of ocular hypertension with oral beta-adrenergic blocking agents.
Acta Ophthalmol (Copenh). 1974;52(4):464-7. doi: 10.1111/j.1755-3768.1974.tb01757.x.
10
The treatment of glaucoma with propranolol (Inderal). A clinical trial.
Acta Ophthalmol (Copenh). 1976 Jul;54(3):291-300. doi: 10.1111/j.1755-3768.1976.tb01258.x.
Zotero 插件