噻吗洛尔与肾上腺素之间的剂量相关相互作用。
Dose-related interaction between timolol and adrenaline.
作者信息
Ohrström A
出版信息
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1981;216(1):55-9. doi: 10.1007/BF00407777.
PMID:6909025
Abstract
The effects on IOP of a combination of oral timolol maleate and adrenaline eye drops were investigated in a double-blind randomized trial using health volunteers. Timolol was given in two doses, 20 and 5 mg a day. One percent adrenaline eye drops were given to one eye, placebo to the other. The results showed a significant additive effect of adrenaline with the smaller dose of timolol, but with the larger dose of timolol the effect of adrenaline was antagonistic. These results may be due to an incomplete beta-blockade with the smaller dose of timolol, but a complete blockade with the larger dose.
摘要
在一项使用健康志愿者的双盲随机试验中，研究了口服马来酸噻吗洛尔与肾上腺素滴眼液联合使用对眼压的影响。噻吗洛尔给予两种剂量，分别为每日20毫克和5毫克。一只眼睛滴入1%的肾上腺素滴眼液，另一只眼睛滴入安慰剂。结果显示，肾上腺素与较小剂量的噻吗洛尔有显著的相加作用，但与较大剂量的噻吗洛尔联合使用时，肾上腺素的作用具有拮抗作用。这些结果可能是由于较小剂量的噻吗洛尔对β受体的阻滞不完全，但较大剂量时则完全阻滞。
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引用本文的文献
1
Dose response of oral timolol combined with adrenaline.口服噻吗洛尔联合肾上腺素的剂量反应。
Br J Ophthalmol. 1982 Apr;66(4):242-6. doi: 10.1136/bjo.66.4.242.
本文引用的文献
1
Timolol and epinephrine: a clinical study of ocular interactions.
Arch Ophthalmol. 1980 Mar;98(3):484-6. doi: 10.1001/archopht.1980.01020030480008.
2
Interaction of timolol and adrenaline.噻吗洛尔与肾上腺素的相互作用。
Br J Ophthalmol. 1981 Jan;65(1):53-5. doi: 10.1136/bjo.65.1.53.
3
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Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1980;213(4):273-81. doi: 10.1007/BF00417550.
4
Regulation of intraocular pressure and pupil size by beta-blockers and epinephrine.
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Br J Clin Pharmacol. 1979 Jun;7(6):575-8. doi: 10.1111/j.1365-2125.1979.tb04645.x.
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Timolol plus maximum-tolerated antiglaucoma therapy.噻吗洛尔加最大耐受量抗青光眼治疗
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A comparison of the effects of timolol and epinephrine on intraocular pressure.
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