罗沙米星和四环素治疗非淋菌性尿道炎。临床和微生物学结果比较。
Rosaramicin and tetracycline in the treatment of non-gonococcal urethritis. A comparison of clinical and microbiological results.
作者信息
Darne J F, Ridgway G L, Oriel J D
出版信息
Br J Vener Dis. 1982 Apr;58(2):117-20. doi: 10.1136/sti.58.2.117.
The clinical and microbiological outcome of the treatment of 94 men for uncomplicated non-gonococcal urethritis (NGU) was studied. Rosaramicin 250 mg six hourly for seven days was given to 46 men and tetracycline 250 mg six hourly for seven days to 48 men; the follow-up period was up to six weeks. Complete resolution of the clinical signs of infection was seen in 40 (87%) of the men treated with rosaramicin and in 37(77%) of those treated with tetracycline. Chlamydia trachomatis was eliminated from 17 of the 18 men treated with rosaramicin and from all of the 16 men treated with tetracycline. Ureaplasma urealyticum was eliminated from 12 of the 14 men treated with rosaramicin and from 15 of the 19 receiving tetracycline. Clinical recovery correlated well with the elimination of C trachomatis but less well with that of U urealyticum. The two antimicrobial agents were equally effective in the therapy of NGU, but gastrointestinal side effects were significantly more common in men treated with rosaramicin.
对94例单纯性非淋菌性尿道炎（NGU）男性患者的治疗临床及微生物学结果进行了研究。46例男性患者接受每6小时250mg罗沙米星治疗，疗程7天；48例男性患者接受每6小时250mg四环素治疗，疗程7天；随访期长达6周。接受罗沙米星治疗的患者中有40例（87%）感染的临床症状完全消退，接受四环素治疗的患者中有37例（77%）出现此情况。接受罗沙米星治疗的18例男性中有17例沙眼衣原体被清除，接受四环素治疗的16例男性中沙眼衣原体全部被清除。接受罗沙米星治疗的14例男性中有12例解脲脲原体被清除，接受四环素治疗的19例男性中有15例解脲脲原体被清除。临床恢复与沙眼衣原体的清除密切相关，但与解脲脲原体的清除相关性较差。这两种抗菌药物在NGU治疗中同样有效，但接受罗沙米星治疗的男性胃肠道副作用明显更常见。
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