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成人线状IgA病中IgA沉积物的超微结构定位

Ultrastructural localization of IgA deposits in adult linear IgA disease.

作者信息

Leonard J N, Haffenden G P, Ring N, Fry L

出版信息

J R Soc Med. 1982 Apr;75(4):237-41.

PMID:7040658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1437626/
Abstract

Two cases of adult linear IgA disease are reported. They demonstrate the two sites of deposition of IgA at an ultrastructural level: sub-basal lamina and lamina lucida. This finding supports the view that there are subgroups of this disease. Clinical presentation and histological appearance of lesional skin are misleading, and the immunofluorescent appearance is unhelpful in predicting the ultrastructural localization of the IgA deposit.

摘要

报告了两例成人线状IgA疾病。它们在超微结构水平上显示了IgA的两个沉积部位：基底层下和透明层。这一发现支持了该疾病存在亚组的观点。皮损的临床表现和组织学表现具有误导性，免疫荧光表现无助于预测IgA沉积物的超微结构定位。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/343c/1437626/ee0e9837c79c/jrsocmed00250-0020-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/343c/1437626/af5ce9fb1e6c/jrsocmed00250-0020-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/343c/1437626/3197fc2c41d3/jrsocmed00250-0020-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/343c/1437626/cee109561c2c/jrsocmed00250-0020-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/343c/1437626/ee0e9837c79c/jrsocmed00250-0020-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/343c/1437626/af5ce9fb1e6c/jrsocmed00250-0020-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/343c/1437626/3197fc2c41d3/jrsocmed00250-0020-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/343c/1437626/cee109561c2c/jrsocmed00250-0020-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/343c/1437626/ee0e9837c79c/jrsocmed00250-0020-d.jpg

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Ultrastructural localization of IgA deposits in adult linear IgA disease.成人线状IgA病中IgA沉积物的超微结构定位
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引用本文的文献

1
Ultrastructural localization of binding sites of sera from patients with linear IgA bullous dermatosis.
Arch Dermatol Res. 1995;287(7):636-40. doi: 10.1007/BF00371735.

本文引用的文献

1
The potassium iodide patch test in the dermatitis herpetiformis in relation to treatment with a gluten-free diet and dapsone.疱疹样皮炎中碘化钾斑贴试验与无麸质饮食及氨苯砜治疗的关系
Br J Dermatol. 1980 Sep;103(3):313-7. doi: 10.1111/j.1365-2133.1980.tb07250.x.
2
Small intestinal biopsies and HLA types in dermatitis herpetiformis patients with granular and linear IgA skin deposits.患有颗粒状和线状IgA皮肤沉积物的疱疹样皮炎患者的小肠活检和HLA类型。
J Invest Dermatol. 1980 Jan;74(1):9-12. doi: 10.1111/1523-1747.ep12514565.
3
Linear IgA dapsone responsive bullous dermatosis.
线性IgA大疱性皮肤病伴氨苯砜反应
J R Soc Med. 1980 May;73(5):371-3. doi: 10.1177/014107688007300515.
4
A study of benign chronic bullous dermatosis of childhood and comparison with dermatitis herpetiformis and bullous pemphigoid occurring in childhood.儿童良性慢性大疱性皮肤病的研究及其与儿童疱疹样皮炎和大疱性类天疱疮的比较。
Clin Exp Dermatol. 1980 Jun;5(2):159-76. doi: 10.1111/j.1365-2230.1980.tb01684.x.
5
IgA bullous pemphigoid: a distinct blistering disorder. Case report and review of the literature.
Br J Dermatol. 1980 Jun;102(6):719-25. doi: 10.1111/j.1365-2133.1980.tb06575.x.
6
The small intestine in dermatitis herpetiformis.疱疹样皮炎中的小肠
J Clin Pathol. 1974 Oct;27(10):817-24. doi: 10.1136/jcp.27.10.817.
7
Clearance of skin lesions in dermatitis herpetiformis after gluten withdrawal.麸质戒断后疱疹样皮炎皮肤损害的消退
Lancet. 1973 Feb 10;1(7798):288-91. doi: 10.1016/s0140-6736(73)91539-0.
8
Immunoglobulins in the skin in dermatitis herpetiformis and coeliac disease.疱疹样皮炎和乳糜泻患者皮肤中的免疫球蛋白
Lancet. 1972 Mar 18;1(7751):611-4. doi: 10.1016/s0140-6736(72)90409-6.
9
Dermatitis herpetiformis and bullous pemphigoid. Intermediate and mixed forms.疱疹样皮炎和大疱性类天疱疮。中间型和混合型。
Arch Dermatol. 1976 Jan;112(1):45-8.
10
Ultrastructural localization of immunoglobulins in skin of patients with dermatitis herpetiformis.疱疹样皮炎患者皮肤中免疫球蛋白的超微结构定位
J Invest Dermatol. 1976 Oct;67(4):507-12. doi: 10.1111/1523-1747.ep12664537.