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疱疹样皮炎中碘化钾斑贴试验与无麸质饮食及氨苯砜治疗的关系

The potassium iodide patch test in the dermatitis herpetiformis in relation to treatment with a gluten-free diet and dapsone.

作者信息

Haffenden G P, Blenkinsopp W K, Ring N P, Wojnarowska F, Fry L

出版信息

Br J Dermatol. 1980 Sep;103(3):313-7. doi: 10.1111/j.1365-2133.1980.tb07250.x.

DOI:10.1111/j.1365-2133.1980.tb07250.x
PMID:7426428
Abstract

The potassium iodide patch test was studied in twenty-six patients with dermatitis herpetiformis. Histological assessment was found more sensitive than clinical. All of five patients with active disease and not on treatment had a positive test, whereas only two of six patients taking a gluten-free diet (GFD) and one of eight taking dapsone were positive. In another two patients taking a GFD, but in whom the diet had not been strict, the test was positive. All three patients in remission and both patients with the linear pattern of IgA (but with active disease) were negative. Immunofluorescence studies showed no difference in the presence, quantity, or distribution of immunoglobulin, complement or fibrinogen between the patch test site and uninvolved skin, or in the uninvolved skin between patients with and without active lesions.

摘要

对26例疱疹样皮炎患者进行了碘化钾斑贴试验。发现组织学评估比临床评估更敏感。5例未接受治疗的活动性疾病患者斑贴试验均为阳性,而6例采用无麸质饮食(GFD)的患者中只有2例阳性,8例服用氨苯砜的患者中只有1例阳性。另外2例采用GFD但饮食不严格的患者斑贴试验为阳性。所有3例缓解期患者以及2例呈IgA线性模式(但为活动性疾病)的患者斑贴试验均为阴性。免疫荧光研究显示,斑贴试验部位与未受累皮肤之间,以及有和无活动性皮损患者的未受累皮肤之间,免疫球蛋白、补体或纤维蛋白原的存在、数量或分布均无差异。

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The potassium iodide patch test in the dermatitis herpetiformis in relation to treatment with a gluten-free diet and dapsone.疱疹样皮炎中碘化钾斑贴试验与无麸质饮食及氨苯砜治疗的关系
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