Shechter Y, Maron R, Elias D, Cohen I R
Science. 1982 Apr 30;216(4545):542-5. doi: 10.1126/science.7041258.
Mice immunized with insulin developed antibodies to both insulin and the insulin receptor. The antibodies to insulin receptor displaced labeled insulin from insulin receptors and mimicked the actions of insulin in stimulating the oxidation of glucose and its incorporation into lipids, and in inhibiting lipolysis. The antibodies to insulin receptor could be blocked by or bound to the antibodies to insulin, and therefore were identified as anti-idiotypes. Thus, immunization against a hormone may activate spontaneously an idiotype-anti-idiotype network resulting in antibodies to the hormone receptor.
用胰岛素免疫的小鼠产生了针对胰岛素和胰岛素受体的抗体。胰岛素受体抗体将标记的胰岛素从胰岛素受体上置换下来，并模拟胰岛素在刺激葡萄糖氧化及其掺入脂质以及抑制脂肪分解方面的作用。胰岛素受体抗体可被胰岛素抗体阻断或与之结合，因此被鉴定为抗独特型抗体。因此，针对一种激素的免疫可能会自发激活独特型-抗独特型网络，从而产生针对激素受体的抗体。
