Couraud P O, Lü B Z, Strosberg A D
J Exp Med. 1983 May 1;157(5):1369-78. doi: 10.1084/jem.157.5.1369.
Antiidiotype antibodies were raised against anti-catecholamine ligand antibodies. The antiidiotype response was shown to be cyclical and to correspond to the production of antibodies that could bind to catecholamine beta-adrenergic receptors and stimulate adenylate cyclase. Disappearance of these antibodies from the serum could be correlated with the appearance of a catecholamine ligand-binding activity corresponding to the synthesis of autologous anti-antiidiotype antibodies directed against the induced antiidiotypic molecules. Comparison of the injected versus the induced anti-ligand antibodies reveals striking differences in affinities but similarities in the ability to bind to the antiidiotype antibodies and to the ligand-containing affinity gel. The results support the existence of a functional network of idiotype antiidiotype interactions involving external as well as internal antigens, antibodies, and possibly other types of molecules involved in recognition phenomena, such as hormone receptors.
抗独特型抗体是针对抗儿茶酚胺配体抗体产生的。抗独特型反应呈周期性，且与能结合儿茶酚胺β - 肾上腺素能受体并刺激腺苷酸环化酶的抗体产生相对应。血清中这些抗体的消失与对应于针对诱导产生的抗独特型分子的自体抗抗独特型抗体合成的儿茶酚胺配体结合活性的出现相关。注射的抗配体抗体与诱导产生的抗配体抗体的比较显示，它们在亲和力上有显著差异，但在与抗独特型抗体及含配体亲和凝胶结合的能力上有相似之处。这些结果支持存在一个独特型 - 抗独特型相互作用的功能网络，该网络涉及外部和内部抗原、抗体，以及可能参与识别现象的其他类型分子，如激素受体。
