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2
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Yeast killer systems.酵母杀伤系统
Clin Microbiol Rev. 1997 Jul;10(3):369-400. doi: 10.1128/CMR.10.3.369.

本文引用的文献

1
Presence of auto-anti-idiotypic antibody during the normal human immune response to tetanus toxoid antigen.在人类对破伤风类毒素抗原的正常免疫反应过程中自身抗独特型抗体的存在。
J Immunol. 1982 Jul;129(1):139-44.
2
Autoantibodies to insulin receptor spontaneously develop as anti-idiotypes in mice immunized with insulin.在用胰岛素免疫的小鼠中，胰岛素受体自身抗体作为抗独特型抗体自发产生。
Science. 1982 Apr 30;216(4545):542-5. doi: 10.1126/science.7041258.
3
The immune response against anti-idiotope antibodies. I. Induction of idiotope-bearing antibodies and analysis of the idiotope repertoire.针对抗独特型抗体的免疫反应。I. 携带独特型抗体的诱导及独特型库分析。
Eur J Immunol. 1982 Dec;12(12):1040-6. doi: 10.1002/eji.1830121210.
4
Immunization of mice against African trypanosomiasis using anti-idiotypic antibodies.使用抗独特型抗体对小鼠进行非洲锥虫病免疫接种。
J Exp Med. 1982 Apr 1;155(4):1108-19. doi: 10.1084/jem.155.4.1108.
5
Detection of interspecies idiotypic cross-reactions associated with antibodies to hepatitis B surface antigen.与乙型肝炎表面抗原抗体相关的种间独特型交叉反应的检测
Eur J Immunol. 1983 Mar;13(3):232-5. doi: 10.1002/eji.1830130310.
6
Cholera and the immune response.霍乱与免疫反应。
Prog Allergy. 1983;33:106-19.
7
Use of monoclonal antibodies to identify shared idiotypes on human antibodies to native DNA from patients with systemic lupus erythematosus.使用单克隆抗体鉴定系统性红斑狼疮患者针对天然DNA的人抗体上的共同独特型。
Proc Natl Acad Sci U S A. 1983 Feb;80(3):850-4. doi: 10.1073/pnas.80.3.850.
8
Peroxidase-labeled antibody. A new method of conjugation.过氧化物酶标记抗体。一种新的偶联方法。
J Histochem Cytochem. 1974 Dec;22(12):1084-91. doi: 10.1177/22.12.1084.
9
Towards a network theory of the immune system.迈向免疫系统的网络理论。
Ann Immunol (Paris). 1974 Jan;125C(1-2):373-89.
10
Anti-thyroglobulin anti-idiotypic antibodies in sera of patients with Hashimoto's thyroiditis and Graves' disease.桥本甲状腺炎和格雷夫斯病患者血清中的抗甲状腺球蛋白抗独特型抗体。
J Immunol. 1986 Dec 15;137(12):3786-95.

一种与抗霍乱毒素反应相关的种间独特型，由单克隆自身抗独特型抗体检测到。

An interspecies idiotope associated with the anti-cholera toxin response detected by a monoclonal auto-anti-idiotypic antibody.

作者信息

Lucas G P, Cambiaso C L, Vaerman J P

机构信息

International Institute of Cellular and Molecular Pathology, Brussels, Belgium.

出版信息

Immunology. 1993 Mar;78(3):498-504.

PMID:8478032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1421829/
Abstract

We have produced an auto-anti-idiotypic (auto-anti-id) monoclonal antibody (mAb) which reacted with syngenic mouse polyclonal anti-cholera toxin (anti-CT) IgG antibody (Ab) and six/eight different anti-CT IgG mAb, but not with normal mouse BALB/c IgG. The binding of this auto-anti-id mAb on one anti-CT mAb was significantly inhibited by polyclonal anti-CT sera of rats, rabbits and mice. Thus the idiotope on anti-CT Ab recognized by this auto-anti-id mAb was public and expressed in different species. Because of the absence of competition between CT and this auto-anti-id mAb for the binding to the six anti-CT mAb, the anti-id mAb was classified as an Ab2 alpha. The efficiency of this auto-anti-id mAb to induce anti-CT Ab3 was tested with success in rabbits and rats. Auto-anti-id mAb-immunized rats were significantly protected against an intraintestinal CT challenge.

摘要

我们制备了一种自身抗独特型（自身抗 - 独特型）单克隆抗体（mAb），它能与同基因小鼠多克隆抗霍乱毒素（抗 - CT）IgG 抗体（Ab）以及六种/八种不同的抗 - CT IgG mAb 发生反应，但不与正常小鼠 BALB/c IgG 反应。大鼠、兔子和小鼠的多克隆抗 - CT 血清能显著抑制这种自身抗 - 独特型 mAb 与一种抗 - CT mAb 的结合。因此，这种自身抗 - 独特型 mAb 所识别的抗 - CT Ab 上的独特型表位是公共的，且在不同物种中都有表达。由于 CT 与这种自身抗 - 独特型 mAb 在与六种抗 - CT mAb 的结合上不存在竞争，所以该抗独特型 mAb 被归类为 Ab2α。在兔子和大鼠中成功测试了这种自身抗 - 独特型 mAb 诱导抗 - CT Ab3 的效率。用自身抗 - 独特型 mAb 免疫的大鼠对肠道内霍乱毒素攻击具有显著的保护作用。