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一种与抗霍乱毒素反应相关的种间独特型，由单克隆自身抗独特型抗体检测到。

An interspecies idiotope associated with the anti-cholera toxin response detected by a monoclonal auto-anti-idiotypic antibody.

作者信息

Lucas G P, Cambiaso C L, Vaerman J P

机构信息

International Institute of Cellular and Molecular Pathology, Brussels, Belgium.

出版信息

Immunology. 1993 Mar;78(3):498-504.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1421829/

Abstract

We have produced an auto-anti-idiotypic (auto-anti-id) monoclonal antibody (mAb) which reacted with syngenic mouse polyclonal anti-cholera toxin (anti-CT) IgG antibody (Ab) and six/eight different anti-CT IgG mAb, but not with normal mouse BALB/c IgG. The binding of this auto-anti-id mAb on one anti-CT mAb was significantly inhibited by polyclonal anti-CT sera of rats, rabbits and mice. Thus the idiotope on anti-CT Ab recognized by this auto-anti-id mAb was public and expressed in different species. Because of the absence of competition between CT and this auto-anti-id mAb for the binding to the six anti-CT mAb, the anti-id mAb was classified as an Ab2 alpha. The efficiency of this auto-anti-id mAb to induce anti-CT Ab3 was tested with success in rabbits and rats. Auto-anti-id mAb-immunized rats were significantly protected against an intraintestinal CT challenge.

摘要

我们制备了一种自身抗独特型（自身抗 - 独特型）单克隆抗体（mAb），它能与同基因小鼠多克隆抗霍乱毒素（抗 - CT）IgG 抗体（Ab）以及六种/八种不同的抗 - CT IgG mAb 发生反应，但不与正常小鼠 BALB/c IgG 反应。大鼠、兔子和小鼠的多克隆抗 - CT 血清能显著抑制这种自身抗 - 独特型 mAb 与一种抗 - CT mAb 的结合。因此，这种自身抗 - 独特型 mAb 所识别的抗 - CT Ab 上的独特型表位是公共的，且在不同物种中都有表达。由于 CT 与这种自身抗 - 独特型 mAb 在与六种抗 - CT mAb 的结合上不存在竞争，所以该抗独特型 mAb 被归类为 Ab2α。在兔子和大鼠中成功测试了这种自身抗 - 独特型 mAb 诱导抗 - CT Ab3 的效率。用自身抗 - 独特型 mAb 免疫的大鼠对肠道内霍乱毒素攻击具有显著的保护作用。