Ziegler I, Kolb H J, Bodenberger U, Wilmanns W
Blut. 1982 May;44(5):261-70. doi: 10.1007/BF00320700.
Bone marrow aplasia was induced by fractionated whole body irradiation with 3000 R and restitution was started by autologous bone marrow transplantation. During the period of aplasia the amount of buffy coat biopterin clearly followed the decline of leukocytes and, vice versa, during reconstitution it largely paralleled their increase in number. The amount of red cell biopterin closely correlated with the number of reticulocytes rather than with the fairly constant values for hematocrit or of erythrocytic protein. Thereby it clearly followed the various periods of red cell recovery. The amount of cellular biopterin, its concentration with respect to cell number or to unit of protein and the percentage distribution of biopterin among the cell fractions are presented as characteristics of the activity of hemopoietic cell proliferation.
采用3000伦琴分次全身照射诱导骨髓再生障碍，通过自体骨髓移植开始恢复过程。在再生障碍期间，血沉棕黄层生物蝶呤的量明显随白细胞数量的减少而减少，反之，在恢复过程中，它在很大程度上与白细胞数量的增加平行。红细胞生物蝶呤的量与网织红细胞数量密切相关，而不是与血细胞比容或红细胞蛋白的相对恒定值相关。因此，它明显地遵循红细胞恢复的各个阶段。细胞生物蝶呤的量、其相对于细胞数量或蛋白质单位的浓度以及生物蝶呤在细胞组分中的百分比分布被作为造血细胞增殖活性的特征呈现出来。
