Hof H, Müller K M, Heine W D
Chemotherapy. 1982;28(2):143-52. doi: 10.1159/000238069.
Niridazole was shown to be an effective chemotherapeutic agent for mice infected intravenously with a niridazole-sensitive strain of Salmonella typhimurium. Death rates as well as bacterial counts per spleen were reduced, even in compromised animals. Histologic examination of spleens proved the reduction of inflammatory reaction due to Salmonella infection. A suppressive effect of niridazole treatment on immunity to challenge infection with S. typhimurium was not found, as demonstrated by infection with a niridazole-resistant strain of S. typhimurium.
已证明硝唑咪对静脉注射感染硝唑咪敏感型鼠伤寒沙门氏菌的小鼠是一种有效的化疗药物。即使在免疫功能受损的动物中，死亡率以及每个脾脏的细菌计数也有所降低。脾脏的组织学检查证明因沙门氏菌感染引起的炎症反应有所减轻。如用硝唑咪耐药型鼠伤寒沙门氏菌感染所证明的那样，未发现硝唑咪治疗对抵抗鼠伤寒沙门氏菌激发感染的免疫力有抑制作用。
