Wiberg U, Mayerová A, Müller U, Fredga K, Wolf U
Hum Genet. 1982;60(2):163-6. doi: 10.1007/BF00569705.
H-Y antigen was investigated in 18 specimens representing six different sex chromosome constitutions of the wood lemming (Myopus schisticolor). The control range of H-Y antigen was defined by the sex difference between normal XX females (H-Y negative per definitionem) and normal XY males (H-Y positive, full titer). H-Y antigen titers of the XY and X0 females were in the male control range, while in the X*X and X0 females the titers were intermediary. Data were obtained with two different H-Y antigen assays: the Raji cell cytotoxicity test and the peroxidase-antiperoxidase (PAP) method. Fibroblasts, gonadal cells, and spleen cells were checked. Presence of full titers of H-Y antigen in the absence of testis differentiation is readily explained by the assumption of a deficiency of the gonad-specific receptor of H-Y antigen. Since sex reversal is inherited as an X-linked trait, genes for this receptor are most likely X-linked. The implications of our findings are discussed in connection with earlier findings concerning H-Y antigen in XY gonadal dysgenesis in man and the X0 situation in man and mouse.
对18个代表木旅鼠（Myopus schisticolor）六种不同性染色体组成的样本进行了H-Y抗原研究。H-Y抗原的对照范围由正常XX雌性（根据定义为H-Y阴性）和正常XY雄性（H-Y阳性，滴度最高）之间的性别差异确定。XY和X0雌性的H-Y抗原滴度处于雄性对照范围内，而X*X和X0雌性的滴度处于中间水平。通过两种不同的H-Y抗原检测方法获得了数据：拉吉细胞细胞毒性试验和过氧化物酶-抗过氧化物酶（PAP）法。对成纤维细胞、性腺细胞和脾细胞进行了检测。在没有睾丸分化的情况下存在H-Y抗原的最高滴度，这可以通过假设H-Y抗原的性腺特异性受体缺乏来轻松解释。由于性反转作为一种X连锁性状遗传，这种受体的基因很可能是X连锁的。结合之前关于人类XY性腺发育不全和人类及小鼠X0情况中H-Y抗原的研究结果，对我们的发现的意义进行了讨论。
