正常小鼠和荷瘤小鼠组织中分泌 IgM、IgA 和 IgG 的细胞分布
Distribution of IgM, IgA and IgG secreting cells in the tissues of normal and tumour-bearing mice.
作者信息
Howie S, McBride W H, James K
出版信息
Immunology. 1982 May;46(1):43-8.
The levels of IgM, IgA and IgG secreting cells were examined in control, Corynebacterium parvum-stimulated and tumour-bearing, normal and athymic (Nu/Nu) mice. The percentage of IgA to IgM or IgG secreting cells is relatively higher in peripheral blood than in the spleen or peritoneum of normal mice. Within tumours, irrespective of their degree of vascularization and immunogenicity, the pattern of Ig secreting cells in similar to that seen in peripheral blood and different from that in spleen and peritoneum even in athymic mice. Intraperitoneal injection of C. parvum changes the relative percentages of Ig secreting cells in the peritoneal cavity to resemble that seen in the peripheral blood and tumours. It appears that Ig secreting cells extravasate from peripheral blood in a non-isotype specific manner into sites of chronic stimulation.
在对照小鼠、经短小棒状杆菌刺激的小鼠以及荷瘤正常小鼠和无胸腺（裸鼠）中检测了分泌 IgM、IgA 和 IgG 的细胞水平。正常小鼠外周血中分泌 IgA 的细胞相对于分泌 IgM 或 IgG 的细胞的百分比，高于脾脏或腹膜中的相应比例。在肿瘤内部，无论其血管化程度和免疫原性如何，分泌 Ig 的细胞模式与外周血中的相似，即使在无胸腺小鼠中也与脾脏和腹膜中的不同。腹腔注射短小棒状杆菌会改变腹腔中分泌 Ig 的细胞的相对百分比，使其类似于外周血和肿瘤中的情况。似乎分泌 Ig 的细胞以非同种型特异性方式从外周血渗出到慢性刺激部位。
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