• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用蛋白A空斑试验检测到的自发分泌抗体的人血淋巴细胞。

Spontaneous antibody-secreting human blood lymphocytes detected with a protein A plaque assay.

作者信息

Kunori T, Broman P, Tan M

出版信息

Clin Exp Immunol. 1980 Oct;42(1):162-6.

PMID:7006874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537057/
Abstract

Spontaneous antibody-secreting lymphocytes in human peripheral blood were detected and counted by a protein A plaque assay. The level of plaque-forming cells (PFC) in peripheral blood was significantly higher in patients with immune disorders (per 10(6) lymphocytes: IgG PFC, 2,654 +/- 684; IgA PFC, 1,727 +/- 327; IgM PFC, 403 +/- 92) than in normal controls (per 10(6) lymphocytes: IgG PFC, 327 +/- 56; IgA PFC 633 +/- 128; IgM PFC, 215 +/- 105). There was no direct correlation between the PFC numbers of different Ig classes.

摘要

采用蛋白A斑片试验检测并计数人外周血中自发分泌抗体的淋巴细胞。免疫紊乱患者外周血中斑形成细胞（PFC）水平显著高于正常对照（每10⁶淋巴细胞：IgG PFC，2654±684；IgA PFC，1727±327；IgM PFC，403±92）（每10⁶淋巴细胞：IgG PFC，327±56；IgA PFC 633±128；IgM PFC，215±105）。不同Ig类别的PFC数量之间无直接相关性。

相似文献

1
Spontaneous antibody-secreting human blood lymphocytes detected with a protein A plaque assay.用蛋白A空斑试验检测到的自发分泌抗体的人血淋巴细胞。
Clin Exp Immunol. 1980 Oct;42(1):162-6.
2
Increased immunoglobulin-secreting cells in the blood of patients with active idiopathic IgA nephropathy.活动性特发性IgA肾病患者血液中分泌免疫球蛋白的细胞增多。
Clin Nephrol. 1986 Oct;26(4):163-8.
3
Secretion of IgM-rheumatoid factor and IgM by blood lymphocytes in rheumatoid arthritis.类风湿关节炎中血液淋巴细胞分泌IgM类风湿因子和IgM
Acta Pathol Microbiol Immunol Scand C. 1983 Feb;91(1):27-33.
4
IgM, IgA and IgG producing cells in cerebrospinal fluid and peripheral blood in multiple sclerosis.多发性硬化症患者脑脊液和外周血中产生IgM、IgA和IgG的细胞
Clin Exp Immunol. 1985 Oct;62(1):176-84.
5
Pokeweed mitogen induced differentiation of human B cells: evaluation by a protein A haemolytic plaque assay.商陆有丝分裂原诱导人B细胞分化：用蛋白A溶血空斑试验进行评估
Immunology. 1979 Sep;38(1):181-9.
6
Clinical evaluation of B cell and T-regulator cell function using a protein A haemolytic plaque assay.使用蛋白A溶血空斑试验对B细胞和T调节细胞功能进行临床评估。
Clin Exp Immunol. 1981 Oct;46(1):196-205.
7
Enumerating immunoglobulin-secreting cells among peripheral human lymphocytes. A hemolytic plaque assay for a B cell function.在外周血人类淋巴细胞中计数免疫球蛋白分泌细胞。一种用于B细胞功能的溶血空斑试验。
J Immunol. 1975 Dec;115(6):1700-3.
8
Immunoglobulin secretion by peripheral blood and bone marrow B cells in patients with multiple myeloma. Studies by the reverse haemolytic plaque assay.多发性骨髓瘤患者外周血和骨髓B细胞的免疫球蛋白分泌。反向溶血空斑试验研究。
Clin Exp Immunol. 1984 Sep;57(3):743-51.
9
Rheumatoid factor-producing cells detected by direct hemolytic plaque assay.通过直接溶血空斑试验检测产生类风湿因子的细胞。
J Clin Invest. 1976 Oct;58(4):933-41. doi: 10.1172/JCI108546.
10
Activation of human B lymphocytes. XV. Spontaneously occurring and mitogen-induced indirect anti-sheep red blood cell plaque-forming cells in normal human peripheral blood.人类B淋巴细胞的激活。十五、正常人外周血中自发产生的和丝裂原诱导的间接抗绵羊红细胞空斑形成细胞
J Immunol. 1980 May;124(5):2410-3.

引用本文的文献

1
Spontaneous antibody-secreting cells in the stomach of gastric cancer patients.
J Gastroenterol. 1996 Apr;31(2):161-6. doi: 10.1007/BF02389512.
2
Pseudoplaque formation by cytophilic immunoglobulins in the sera of lupus patients as measured using reverse haemolytic plaque assay.使用反向溶血空斑试验检测狼疮患者血清中嗜细胞性免疫球蛋白形成的假斑块。
Clin Exp Immunol. 1982 May;48(2):499-504.
3
Distribution of IgM, IgA and IgG secreting cells in the tissues of normal and tumour-bearing mice.正常小鼠和荷瘤小鼠组织中分泌 IgM、IgA 和 IgG 的细胞分布
Immunology. 1982 May;46(1):43-8.
4
Clinical evaluation of B cell and T-regulator cell function using a protein A haemolytic plaque assay.使用蛋白A溶血空斑试验对B细胞和T调节细胞功能进行临床评估。
Clin Exp Immunol. 1981 Oct;46(1):196-205.
5
In vitro effects of human lipoproteins on the immune system in healthy donors: inhibition of plaque forming cell generation and decreased frequency of NK cells.人脂蛋白对健康供体免疫系统的体外作用：抑制噬斑形成细胞生成并降低自然杀伤细胞频率。
Clin Exp Immunol. 1984 Jun;56(3):677-82.

本文引用的文献

1
Lymphoid cellular responses in the blood after immunization in man.人体免疫后血液中的淋巴细胞反应。
J Exp Med. 1969 May 1;129(5):849-69. doi: 10.1084/jem.129.5.849.
2
The atypical lymphocyte.异型淋巴细胞。
Am J Med. 1967 Jun;42(6):923-36. doi: 10.1016/0002-9343(67)90073-3.
3
A plaque assay for all cells secreting Ig of a given type or class.针对所有分泌特定类型或类别的免疫球蛋白的细胞进行的噬斑测定。
Eur J Immunol. 1976 Aug;6(8):588-90. doi: 10.1002/eji.1830060812.
4
Activation of human B lymphocytes. I. Direct plaque-forming cell assay for the measurement of polyclonal activation and antigenic stimulation of human B lymphocytes.人类B淋巴细胞的激活。I. 用于测量人类B淋巴细胞多克隆激活和抗原刺激的直接空斑形成细胞测定法。
J Exp Med. 1976 Sep 1;144(3):674-84. doi: 10.1084/jem.144.3.674.
5
Induction of antibody synthesis in human B lymphocytes by different polyclonal B cell activators: evaluation by direct and indirect PFC assays.不同多克隆B细胞激活剂对人B淋巴细胞抗体合成的诱导作用：通过直接和间接空斑形成细胞试验进行评估
Immunol Rev. 1979;45:195-218. doi: 10.1111/j.1600-065x.1979.tb00278.x.
6
Optimal conditions for polyclonal antibody secretion and DNA synthesis in human blood and spleen lymphocytes by lipopolysaccharide.脂多糖诱导人血及脾淋巴细胞分泌多克隆抗体和进行DNA合成的最佳条件。
Scand J Immunol. 1978;8(5):451-8. doi: 10.1111/j.1365-3083.1978.tb00541.x.
7
Polyclonal antibody secretion in human lymphocytes induced by killed staphylococcal bacteria and by lipopolysaccharide.由灭活葡萄球菌和脂多糖诱导的人淋巴细胞中的多克隆抗体分泌。
Scand J Immunol. 1977;6(11):1159-69. doi: 10.1111/j.1365-3083.1977.tb00355.x.
8
The use of bacteria for the functional characterization of human lymphocyte subpopulations in various lymphoid organs.
Scand J Immunol. 1978;8(5):369-75. doi: 10.1111/j.1365-3083.1978.tb00531.x.