Kato K, Yamamoto K
Infect Immun. 1982 Apr;36(1):426-9. doi: 10.1128/iai.36.1.426-429.1982.
We previously showed the suppression of delayed-type hypersensitivity produced by live BCG-induced, plastic-adhering cells. The present study was undertaken to determine whether prostaglandin was one of the pharmacological mediators involved in this suppression. A high level of prostaglandin E1 was detected in the culture supernatant fluid of the live BCG-induced, adherent cells. Moreover, prostaglandin E1 could suppress the macrophage migration inhibition activity of peritoneal exudate cells from BCG cell wall-sensitized mice.
我们之前发现,活卡介苗诱导产生的、可黏附于塑料的细胞能抑制迟发型超敏反应。本研究旨在确定前列腺素是否为参与这种抑制作用的药理介质之一。在活卡介苗诱导产生的黏附细胞的培养上清液中检测到高水平的前列腺素E1。此外,前列腺素E1能抑制卡介苗细胞壁致敏小鼠腹腔渗出细胞的巨噬细胞移动抑制活性。