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前列腺素E1参与牛型结核分枝杆菌活菌诱导的迟发型超敏反应抑制。

Involvement of prostaglandin E1 in delayed-type hypersensitivity suppression induced with live Mycobacterium bovis BCG.

作者信息

Kato K, Yamamoto K

出版信息

Infect Immun. 1982 Apr;36(1):426-9. doi: 10.1128/iai.36.1.426-429.1982.

DOI:10.1128/iai.36.1.426-429.1982
PMID:7042574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC351236/
Abstract

We previously showed the suppression of delayed-type hypersensitivity produced by live BCG-induced, plastic-adhering cells. The present study was undertaken to determine whether prostaglandin was one of the pharmacological mediators involved in this suppression. A high level of prostaglandin E1 was detected in the culture supernatant fluid of the live BCG-induced, adherent cells. Moreover, prostaglandin E1 could suppress the macrophage migration inhibition activity of peritoneal exudate cells from BCG cell wall-sensitized mice.

摘要

我们之前发现，活卡介苗诱导产生的、可黏附于塑料的细胞能抑制迟发型超敏反应。本研究旨在确定前列腺素是否为参与这种抑制作用的药理介质之一。在活卡介苗诱导产生的黏附细胞的培养上清液中检测到高水平的前列腺素E1。此外，前列腺素E1能抑制卡介苗细胞壁致敏小鼠腹腔渗出细胞的巨噬细胞移动抑制活性。

相似文献

1
Involvement of prostaglandin E1 in delayed-type hypersensitivity suppression induced with live Mycobacterium bovis BCG.前列腺素E1参与牛型结核分枝杆菌活菌诱导的迟发型超敏反应抑制。
Infect Immun. 1982 Apr;36(1):426-9. doi: 10.1128/iai.36.1.426-429.1982.
2
Suppression of BCG cell wall induced delayed-type hypersensitivity by BCG pre-treatment. I. Induction of adherent suppressor cells by live BCG injection and their characterization.卡介苗预处理对卡介苗细胞壁诱导的迟发型超敏反应的抑制作用。I. 活卡介苗注射诱导黏附性抑制细胞及其特性研究
Immunology. 1981 Feb;42(2):259-66.
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Migration of natural suppressor cells from bone marrow to peritoneal cavity by live BCG.活卡介苗介导自然抑制细胞从骨髓迁移至腹腔。
J Immunol. 1985 Dec;135(6):3661-8.
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Non-specific suppression of delayed-type hypersensitivity by intrathymic injection of killed bacteria.胸腺内注射死菌对迟发型超敏反应的非特异性抑制作用
Thymus. 1984;6(1-2):79-87.
5
Suppression of BCG cell wall-induced delayed-type hypersensitivity by pretreatment with killed BCG: induction of nonspecific suppressor T cells by the adjuvant portion (MDP) and of specific suppressor T cells by the antigen portion (TAP).用灭活卡介苗预处理对卡介苗细胞壁诱导的迟发型超敏反应的抑制作用：佐剂部分（MDP）诱导非特异性抑制性T细胞，抗原部分（TAP）诱导特异性抑制性T细胞。
J Immunol. 1984 Jun;132(6):2790-5.
6
Relationship of macrophages to defective delayed-type hypersensitivity in B6/lpr mice.B6/lpr小鼠中巨噬细胞与缺陷性迟发型超敏反应的关系。
Clin Exp Immunol. 1986 Dec;66(3):599-605.
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Restoration of suppressed delayed-type hypersensitivity induced in mice by live BCG after methotrexate administration.甲氨蝶呤给药后，活卡介苗诱导的小鼠体内被抑制的迟发型超敏反应的恢复。
Int J Immunopharmacol. 1982;4(5):463-7. doi: 10.1016/0192-0561(82)90021-2.
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[Dynamic aspects of immunocompetent cells for delayed hypersensitivity. Relationship between macrophage migration inhibition phenomenon and delayed skin reaction (author's transl)].[迟发型超敏反应中免疫活性细胞的动态方面。巨噬细胞游走抑制现象与迟发型皮肤反应之间的关系（作者译）]
Kekkaku. 1974 May;49(5):117-25.
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Suppression of BCG cell wall-induced delayed-type hypersensitivity by BCG pre-treatment. II. Induction of suppressor T cells by heat-killed BCG injection.卡介苗预处理对卡介苗细胞壁诱导的迟发型超敏反应的抑制作用。II. 热灭活卡介苗注射诱导抑制性T细胞
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Differential effects of prostaglandins on the antitumor activity of normal and BCG-activated macrophages.前列腺素对正常及卡介苗激活巨噬细胞抗肿瘤活性的不同作用。
Cell Immunol. 1981 May 1;60(1):91-9. doi: 10.1016/0008-8749(81)90250-1.

引用本文的文献

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Am J Pathol. 1983 Apr;111(1):78-87.
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Suppression of cellular immunity to Listeria monocytogenes by activated macrophages: mediation by prostaglandins.活化巨噬细胞对单核细胞增生李斯特菌细胞免疫的抑制作用：前列腺素的介导作用
Infect Immun. 1985 Aug;49(2):383-8. doi: 10.1128/iai.49.2.383-388.1985.
4
Relationship of macrophages to defective delayed-type hypersensitivity in B6/lpr mice.B6/lpr小鼠中巨噬细胞与缺陷性迟发型超敏反应的关系。
Clin Exp Immunol. 1986 Dec;66(3):599-605.

本文引用的文献

1
Macrophage-mediated suppression. I. Evidence for participation of both hdyrogen peroxide and prostaglandins in suppression of murine lymphocyte proliferation.巨噬细胞介导的抑制作用。I. 过氧化氢和前列腺素参与抑制小鼠淋巴细胞增殖的证据。
J Immunol. 1980 Feb;124(2):983-8.
2
Suppression of BCG cell wall induced delayed-type hypersensitivity by BCG pre-treatment. I. Induction of adherent suppressor cells by live BCG injection and their characterization.卡介苗预处理对卡介苗细胞壁诱导的迟发型超敏反应的抑制作用。I. 活卡介苗注射诱导黏附性抑制细胞及其特性研究
Immunology. 1981 Feb;42(2):259-66.
3
Radioimmunoassay for prostaglandins.前列腺素的放射免疫测定法。
Science. 1971 Feb 5;171(3970):494-6. doi: 10.1126/science.171.3970.494.
4
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.抑制前列腺素合成作为阿司匹林类药物的作用机制。
Nat New Biol. 1971 Jun 23;231(25):232-5. doi: 10.1038/newbio231232a0.
5
Effect of prostaglandin E 1 on adjuvant arthritis.前列腺素E1对佐剂性关节炎的影响。
Nature. 1971 Dec 3;234(5327):304-5. doi: 10.1038/234304a0.
6
Radioimmunoassay measurement of prostaglandins E, A, and F in human plasma.人血浆中前列腺素E、A和F的放射免疫分析测定
J Clin Invest. 1973 Feb;52(2):398-405. doi: 10.1172/JCI107196.
7
[Studies on extraction, separation and estimation of prostaglandins by radioimmunoassay].
Yakugaku Zasshi. 1972 Oct;92(10):1187-94. doi: 10.1248/yakushi1947.92.10_1187.
8
Prostaglandin E 1 as a regulator of lymphocyte function. Selective action on B lymphocytes and synergy with procarbazine in depression of immune responses.前列腺素E1作为淋巴细胞功能的调节剂。对B淋巴细胞的选择性作用以及与丙卡巴肼在免疫反应抑制中的协同作用。
Cell Immunol. 1973 Mar;6(3):457-65. doi: 10.1016/0008-8749(73)90044-0.
9
Biological effects of the adjuvant Corynebacterium parvum. II. Evidence for macrophage-T-cell interaction.佐剂短小棒状杆菌的生物学效应。II. 巨噬细胞与T细胞相互作用的证据。
Cell Immunol. 1972 Nov;5(3):469-79. doi: 10.1016/0008-8749(72)90073-1.
10
Hemolytic plaque formation by leukocytes in vitro. Control by vasoactive hormones.白细胞在体外形成溶血空斑。血管活性激素的调控
J Clin Invest. 1974 Jan;53(1):13-21. doi: 10.1172/JCI107530.