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两种相关细菌多糖上唾液酸的存在决定了初次免疫反应的部位以及补体耗竭对小鼠免疫反应的影响。

The presence of sialic acid on two related bacterial polysaccharides determines the site of the primary immune response and the effect of complement depletion on the response in mice.

作者信息

Markham R B, Nicholson-Weller A, Schiffman G, Kasper D L

出版信息

J Immunol. 1982 Jun;128(6):2731-3.

PMID:7042846
Abstract

We have examined the antibody responses in mice to two structurally similar antigens: the capsular polysaccharide of type 3 group B streptococci (sssGBS 3) and the capsular polysaccharide of type 14 pneumococci (sssPn 14), which differ only in the presence of a terminal sialic acid on the side chain of the former. The cells that produce antibody to the nonsialated antigen (sssPn 14) reside in the spleen, whereas the cells that produce antibody to the sialated antigen (sssGBS 3) do not. Cobra venom factor treatment of the mice before immunization abrogates the antibody response to the nonsialated antigen, but does not affect the response to the sialated antigen.

摘要

我们研究了小鼠对两种结构相似抗原的抗体反应

B族3型链球菌的荚膜多糖（sssGBS 3）和14型肺炎球菌的荚膜多糖（sssPn 14），它们的区别仅在于前者侧链上存在末端唾液酸。产生针对非唾液酸化抗原（sssPn 14）抗体的细胞存在于脾脏中，而产生针对唾液酸化抗原（sssGBS 3）抗体的细胞则不存在。免疫前用眼镜蛇毒因子处理小鼠可消除对非唾液酸化抗原的抗体反应，但不影响对唾液酸化抗原的反应。

相似文献

1
The presence of sialic acid on two related bacterial polysaccharides determines the site of the primary immune response and the effect of complement depletion on the response in mice.两种相关细菌多糖上唾液酸的存在决定了初次免疫反应的部位以及补体耗竭对小鼠免疫反应的影响。
J Immunol. 1982 Jun;128(6):2731-3.
2
Depletion of complement has distinct effects on the primary and secondary antibody responses to a conjugate of pneumococcal serotype 14 capsular polysaccharide and a T-cell-dependent protein carrier.补体的耗竭对针对肺炎球菌14型荚膜多糖与T细胞依赖性蛋白载体结合物的初次和二次抗体反应有不同影响。
Infect Immun. 2005 Jan;73(1):277-86. doi: 10.1128/IAI.73.1.277-286.2005.
3
Influence of cobra venom (CoF) and pneumococcal S III capsular polysaccharide on immunologic humoral response and visceral distribution of antigens.眼镜蛇毒（CoF）和肺炎球菌SⅢ荚膜多糖对免疫体液反应及抗原在脏器中分布的影响。
Arch Immunol Ther Exp (Warsz). 1977;25(4):469-75.
4
Capsular sialic acid prevents activation of the alternative complement pathway by type III, group B streptococci.荚膜唾液酸可防止B族Ⅲ型链球菌激活替代补体途径。
J Immunol. 1982 Mar;128(3):1278-83.
5
Minimal role for the spleen in antibody responses of C57BR/cdj mice to pneumococcal polysaccharide antigens.脾脏在C57BR/cdj小鼠对肺炎球菌多糖抗原的抗体反应中作用极小。
Clin Exp Immunol. 1988 Apr;72(1):151-6.
6
Influence of preimmunization antibody levels on the specificity of the immune response to related polysaccharide antigens.免疫前抗体水平对针对相关多糖抗原的免疫反应特异性的影响。
N Engl J Med. 1980 Jul 24;303(4):173-8. doi: 10.1056/NEJM198007243030401.
7
Immunodeterminant specificity of human immunity to type III group B streptococcus.人类对B族链球菌III型免疫的免疫决定簇特异性。
J Exp Med. 1979 Feb 1;149(2):327-39. doi: 10.1084/jem.149.2.327.
8
Opsonic properties of C-reactive protein in vivo.体内C反应蛋白的调理素特性
J Immunol. 1982 Jun;128(6):2435-8.
9
Maternal immunization of mice with group B streptococcal type III polysaccharide-beta C protein conjugate elicits protective antibody to multiple serotypes.用B族链球菌III型多糖-β C蛋白共轭物对小鼠进行母体免疫可引发针对多种血清型的保护性抗体。
J Clin Invest. 1994 Jul;94(1):286-92. doi: 10.1172/JCI117319.
10
Morphology of the antibody response to pneumococcal polysaccharide in mice.小鼠对肺炎球菌多糖抗体反应的形态学
J Hyg Epidemiol Microbiol Immunol. 1979;23(2):226-34.

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