Delidakis C E, Jones-Mortimer M C, Kornberg H L
J Gen Microbiol. 1982 Mar;128(3):601-4. doi: 10.1099/00221287-128-3-601.
Galactitol-positive strains of Escherichia coli K12 are inhibited by the galactitol analogues L-fucitol and 2-deoxy-D-galactitol, but not by D-fucitol; Salmonella typhimurium LT2 is not inhibited by these compounds. Most mutants selected as resistant to either toxic compound are unable to utilize galactitol as carbon source, but a relatively rare class is inducible for the Enzyme II of the galactitol:phosphoenolpyruvate phosphotransferase system, the product of which is D-galactitol 6-phosphate. The lesion in one such mutant maps near metG at about min 45 on the E. coli genome.
大肠杆菌K12的半乳糖醇阳性菌株会被半乳糖醇类似物L-岩藻糖和2-脱氧-D-半乳糖醇抑制，但不会被D-岩藻糖抑制；鼠伤寒沙门氏菌LT2不会被这些化合物抑制。大多数被选为对任何一种有毒化合物具有抗性的突变体都无法利用半乳糖醇作为碳源，但相对罕见的一类突变体可诱导半乳糖醇：磷酸烯醇丙酮酸磷酸转移酶系统的酶II，其产物是6-磷酸-D-半乳糖醇。其中一个这样的突变体中的损伤位于大肠杆菌基因组上约45分钟处的metG附近。
