Been V, Engel D
J Periodontol. 1982 Apr;53(4):245-8. doi: 10.1902/jop.1982.53.4.245.
The periodontal status of four kidney allograft patients was determined before and at periodic intervals for 9 months after receipt of the allografts. These patients received immunosuppressive drugs as part of their therapy, beginning at the time of transplantation. Three hemodialysis patients with analogous kidney disease and six eye patients who were otherwise healthy served as controls. Comparisons of plaque levels, pocket depths and gingival inflammation were made between the three groups of subjects. The results suggest that the administration of the immunosuppressive drugs significantly reduces the level of gingival inflammation in the presence of high levels of bacterial plaque. Pocket depths did not change significantly in eigher the allograft or control groups. Whole not conclusive, the findings support the hypothesis that host inflammatory and immunological responsiveness to plaque bacteria is a primary factor in the pathogenesis of destructive periodontal disease in humans.
对4例肾移植患者在接受移植前及移植后的9个月内定期进行牙周状况测定。这些患者从移植时开始接受免疫抑制药物治疗。3例患有类似肾病的血液透析患者和6例其他方面健康的眼科患者作为对照。对三组受试者的菌斑水平、牙周袋深度和牙龈炎症进行了比较。结果表明，在存在高水平菌斑的情况下，免疫抑制药物的使用显著降低了牙龈炎症水平。移植组和对照组的牙周袋深度均无显著变化。尽管结果尚无定论，但这些发现支持了以下假设，即宿主对菌斑细菌的炎症和免疫反应是人类破坏性牙周病发病机制中的一个主要因素。
