Schölkens B A, Gehring D, Schlotte V, Weithmann U
Prostaglandins Leukot Med. 1982 Mar;8(3):273-85. doi: 10.1016/0262-1746(82)90050-6.
Polyunsaturated fatty acids (PUFA) are biosynthetic precursors of prostaglandins (PG). Endogenous biosynthesis of PG in vessel wall and kidney contributes to the regulation of arterial blood pressure. By increasing the fraction of PUFA in the diet systemic blood pressure can be lowered while PUFA deficient diet leads to an increase in blood pressure. To evaluate the effect of an enhanced PG biosynthesis by dietary PG precursors on vascular reactivity and vascular formation of prostacyclin-like activity, the pressor response to intravenous renin and angiotensin II in rats pretreated p.o. for 3 months with evening primrose oil (EPO, 1 ml/day) was determined and the antiaggregatory activity released by aortas of treated rats studied. EPO is unique in that it contains beside linoleic acid (72%), gamma-linolenic acid itself (9%). In contrast to olive oil treated rats EPO pretreatment diminished vascular reactivity to the vasopressor stimuli of renin and angiotensin II and increased the formation of vascular prostacyclin-like activity (p less than 0.05). These studies imply the possibility of a selective modulation of PG production by dietary maneuvers.
多不饱和脂肪酸（PUFA）是前列腺素（PG）的生物合成前体。血管壁和肾脏中PG的内源性生物合成有助于调节动脉血压。通过增加饮食中PUFA的比例可以降低全身血压，而缺乏PUFA的饮食则会导致血压升高。为了评估饮食中PG前体增强PG生物合成对血管反应性和前列环素样活性血管形成的影响，测定了经口给予月见草油（EPO，1 ml/天）预处理3个月的大鼠对静脉注射肾素和血管紧张素II的升压反应，并研究了处理后大鼠主动脉释放的抗聚集活性。EPO的独特之处在于，除了亚油酸（72%）外，它本身还含有γ-亚麻酸（9%）。与橄榄油处理的大鼠相比，EPO预处理降低了血管对肾素和血管紧张素II升压刺激的反应性，并增加了血管前列环素样活性的形成（p<0.05）。这些研究表明通过饮食调控选择性调节PG生成的可能性。
