β-珠蛋白信使核糖核酸前体的序列组织
Sequence organization of the beta-globin mRNA precursor.
作者信息
Smith K, Lingrel J B
出版信息
Nucleic Acids Res. 1978 Sep;5(9):3295-301. doi: 10.1093/nar/5.9.3295.
Abstract
The sequence organization of the beta-globin mRNA precursor has been determined directly by analyzing the resistant fragments from the RNase A digestion of the precursor RNA-globin cDNA hybrid. Three fragments are obtained which proves that the beta-globin mRNA sequence in its precursor is split into three discontinuous segments. The two intervening sequences in the beta-globin gene are therefore transcribed and removed during mRNA maturation.
摘要
通过分析β-珠蛋白mRNA前体RNA与珠蛋白cDNA杂交体经核糖核酸酶A消化后的抗性片段，直接确定了β-珠蛋白mRNA前体的序列组织。获得了三个片段，这证明其前体中的β-珠蛋白mRNA序列被分割成三个不连续的片段。因此，β-珠蛋白基因中的两个间隔序列在mRNA成熟过程中被转录并去除。
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Proc Natl Acad Sci U S A. 1978 Dec;75(12):6187-91. doi: 10.1073/pnas.75.12.6187.
本文引用的文献
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Biochemistry. 1968 Feb;7(2):668-74. doi: 10.1021/bi00842a023.
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A precursor of globin messenger RNA.珠蛋白信使核糖核酸的前体。
J Mol Biol. 1976 Sep 15;106(2):403-20. doi: 10.1016/0022-2836(76)90093-0.
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Purification of globin messenger RNA from dimethylsulfoxide-induced Friend cells and detection of a putative globin messenger RNA precursor.从二甲基亚砜诱导的弗瑞德细胞中纯化珠蛋白信使核糖核酸并检测一种假定的珠蛋白信使核糖核酸前体。
J Mol Biol. 1976 Oct 5;106(4):1067-75. doi: 10.1016/0022-2836(76)90353-3.
4
The location of the globin mRNA sequence within its 16S precursor.珠蛋白信使核糖核酸序列在其16S前体中的位置。
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5
The rabbit beta-globin gene contains a large large insert in the coding sequence.兔β-珠蛋白基因在编码序列中含有一个大的插入片段。
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Nature. 1977 Nov 24;270(5635):314-9. doi: 10.1038/270314a0.
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Presence of a putative 15S precursor to beta-globin mRNA but not to alpha-globin mRNA in Friend cells.弗瑞德（Friend）细胞中存在β-珠蛋白mRNA的假定15S前体，但不存在α-珠蛋白mRNA的假定15S前体。
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