新型铁螯合剂——超级多酚，对致龋菌显示出抗菌作用。

Novel Iron Chelators, Super-Polyphenols, Show Antimicrobial Effects against Cariogenic .

作者信息

Shinoda-Ito Yuki, Omori Kazuhiro, Ito Takashi, Nakayama Masaaki, Ikeda Atsushi, Ito Masahiro, Ohara Toshiaki, Takashiba Shogo

机构信息

Department of Pathophysiology-Periodontal Science, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8525, Japan.

Center for Innovative Clinical Medicine, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.

出版信息

Antibiotics (Basel). 2023 Oct 24;12(11):1562. doi: 10.3390/antibiotics12111562.

DOI:10.3390/antibiotics12111562

PMID:37998764

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10668666/

Abstract

Dental caries are an oral infectious disease that can affect human health both orally and systemically. It remains an urgent issue to establish a novel antibacterial method to prevent oral infection for a healthy life expectancy. The aim of this study was to evaluate the inhibitory effects of novel iron chelators, super-polyphenols (SPs), on the cariogenic bacterium , in vitro. SPs were developed to reduce the side effects of iron chelation therapy and were either water-soluble or insoluble depending on their isoforms. We found that SP6 and SP10 inhibited bacterial growth equivalent to povidone-iodine, and viability tests indicated that their effects were bacteriostatic. These results suggest that SP6 and SP10 have the potential to control oral bacterial infections such as .

摘要

龋齿是一种口腔感染性疾病，会对人类口腔健康和全身健康产生影响。建立一种新型抗菌方法以预防口腔感染从而实现健康预期寿命仍然是一个紧迫的问题。本研究的目的是在体外评估新型铁螯合剂超多酚（SPs）对致龋菌的抑制作用。开发SPs是为了减少铁螯合疗法的副作用，根据其异构体的不同，它们有的可溶于水，有的不溶于水。我们发现SP6和SP10抑制细菌生长的效果与聚维酮碘相当，活力测试表明它们的作用是抑菌性的。这些结果表明，SP6和SP10有控制诸如……等口腔细菌感染的潜力。