Levin A
S Afr Med J. 1982 May 8;61(19):701-4.
Forty-two patients aged between 19 and 70 years (30 women and 12 men) suffering from primary unipolar depression were randomly selected and treated under double-blind conditions with either mianserin (Lantanon; Organon) or clomipramine (Anafranil; Ciba-Geigy) after an initial wash-out period. Patients on all other medication, including benzodiazepines, were excluded from the study. The severity of depression was assessed on day 0 and after 1, 2, 3, 4 and 5 weeks' treatment. There were no significant pretrial differences between the groups in respect of severity of depression, age, sex or previous psychiatric history. During the 1st week of treatment all subjects received either mianserin 30 mg or clomipramine 75 mg once daily. From the 2nd week onwards the dose was doubled. Thirty patients completed the trial, 16 on mianserin and 14 on clomipramine. The improvement on both treatments was marked, favouring mianserin but only reaching significance in the 5th week. Side-effects, especially tremor, tachycardia, dystonia, dizziness, excitement, nasal congestion and dry mouth, were significantly more common in the group using clomipramine. This study confirms reports that mianserin is an effective antidepressant which is better tolerated and produces fewer side-effects (especially anticholinergic) than comparable tricyclic antidepressants such as clomipramine.
随机选取42例年龄在19至70岁之间（30名女性和12名男性）的原发性单相抑郁症患者，在经过初始洗脱期后，采用双盲法分别用米安色林（Lantanon；欧加农公司）或氯米帕明（Anafranil；汽巴 - 嘉基公司）进行治疗。所有正在服用包括苯二氮䓬类药物在内的其他药物的患者被排除在研究之外。在治疗第0天以及治疗1、2、3、4和5周后评估抑郁严重程度。两组在抑郁严重程度、年龄、性别或既往精神病史方面治疗前无显著差异。在治疗的第1周，所有受试者每天服用一次30毫克米安色林或75毫克氯米帕明。从第2周起剂量加倍。30名患者完成了试验，16名服用米安色林，14名服用氯米帕明。两种治疗方法均有显著改善，米安色林效果更佳，但仅在第5周达到显著差异。使用氯米帕明的组中副作用，尤其是震颤、心动过速、肌张力障碍、头晕、兴奋、鼻塞和口干明显更为常见。本研究证实了有关米安色林是一种有效抗抑郁药的报道，与氯米帕明等类似三环类抗抑郁药相比，它耐受性更好，副作用（尤其是抗胆碱能副作用）更少。
