Hanifin J M
J Am Acad Dermatol. 1982 Jan;6(1):1-13. doi: 10.1016/s0190-9622(82)70001-5.
Atopic dermatitis is a chronically relapsing inflammatory skin disease with altered immune and pharmacologic responses. Elevated serum IgE probably reflects defective immune regulation. Various other cellular immune defects rise and fall exacerbations and remissions of skin inflammation. Increased responsiveness to cholinergic and alpha adrenergic agents may relate to abnormalities of cyclic nucleotide regulation. Recent observations of abnormal cyclic adenosine monophosphate (cAMP)-phosphodiesterase activity in atopic dermatitis may provide new insights into the pathogenesis and treatment of the disease.
特应性皮炎是一种具有免疫和药理反应改变的慢性复发性炎症性皮肤病。血清IgE升高可能反映了免疫调节缺陷。各种其他细胞免疫缺陷随着皮肤炎症的加重和缓解而起伏。对胆碱能和α肾上腺素能药物反应性增加可能与环核苷酸调节异常有关。最近关于特应性皮炎中环磷酸腺苷（cAMP）-磷酸二酯酶活性异常的观察可能为该疾病的发病机制和治疗提供新的见解。
