Kimata H, Hiratsuka S
Department of Paediatrics, Shinkori Hospital, Hirakata City, Osaka, Japan.
Eur J Pediatr. 1994 Feb;153(2):66-71. doi: 10.1007/BF01959209.
The effect of topically applied sodium cromoglycate solution in moderate to severe atopic dermatitis (AD) in children aged 4-14 years was studied in a double-blind, placebo-controlled, randomized group-comparative trial. One group of patients was treated with topical sodium cromoglycate solution and oral oxatomide whereas the other group was treated with topical placebo solution and oral oxatomide. After 4 weeks, AD improved significantly in the group treated with the sodium cromoglycate solution and oxatomide combination while marginal improvement was noted in the placebo. In addition, spontaneous IgE production from peripheral blood mononuclear cells decreased significantly in the sodium cromoglycate group but not in the placebo group. These results suggest that sodium cromoglycate solution may be very effective in combination with anti-allergic medication in the treatment of moderate to severe AD in children.
在一项双盲、安慰剂对照、随机分组比较试验中，研究了局部应用色甘酸钠溶液对4至14岁儿童中度至重度特应性皮炎（AD）的疗效。一组患者接受局部色甘酸钠溶液和口服奥沙米特治疗，而另一组患者接受局部安慰剂溶液和口服奥沙米特治疗。4周后，色甘酸钠溶液和奥沙米特联合治疗组的AD有显著改善，而安慰剂组仅有轻微改善。此外，色甘酸钠组外周血单核细胞自发产生的IgE显著减少，而安慰剂组未减少。这些结果表明，色甘酸钠溶液与抗过敏药物联合使用可能对治疗儿童中度至重度AD非常有效。
