Degtiarev V P
Farmakol Toksikol. 1977 Mar-Apr;40(2):141-6.
Introduction of the M-cholinomimetic -- arecoline into the ventricle of the rabbit's brain decreases and of the M-cholinolytic -- atropine -- increases the amplitude of primary responses in the sensomotor region of the cortex, arising out of stimulating the dental pulp. The N-cholinomimetic -- lobeline potentiates the evoked response of the brain cortex, whereas the N-cholinolytic -- beta-ethylene-splasmolytin -- depresses it. It is assumed that the region of the drugs action application are thalamic nuclei.
将拟毒蕈碱样物质——槟榔碱注入兔脑室会使因刺激牙髓而在皮层感觉运动区产生的初级反应幅度降低，而注入抗毒蕈碱样物质——阿托品则会使其增加。拟烟碱样物质——洛贝林可增强大脑皮层的诱发反应，而抗烟碱样物质——β-乙烯溶血素则会抑制该反应。据推测，药物作用的区域是丘脑核。
