Soltész G, Molnár D, Klujber L, Kardos M
Acta Paediatr Acad Sci Hung. 1982;23(1):75-83.
All lipid and lipoprotein fractions except for total cholesterol were found to be high in diabetic children under long-term treatment. There was a positive correlation between HDL-cholesterol, HbA1a-c and the insulin dose. In untreated diabetic children, plasma triglyceride and its subfractions were also high, but phospholipids were normal. Total plasma cholesterol was normal, but its VLDL + LDL subfraction was increased and HDL-cholesterol low. After two months of insulin-treatment, parallel with the decrease of HbA1a-c, the HDL-cholesterol increased and there was a drop in the level of triglycerides. It is concluded that HDL-cholesterol is a good parameter of metabolic control during the initial therapy of diabetes. In patients under long-term treatment there is no such a simple relationship between control and HDL-cholesterol and the daily insulin-dose seems to play an important role in the regulation of plasma HDL-cholesterol.
研究发现，长期接受治疗的糖尿病儿童除总胆固醇外，所有脂质和脂蛋白组分均偏高。高密度脂蛋白胆固醇（HDL-胆固醇）、糖化血红蛋白A1a-c（HbA1a-c）与胰岛素剂量之间呈正相关。未经治疗的糖尿病儿童血浆甘油三酯及其亚组分也偏高，但磷脂正常。血浆总胆固醇正常，但其极低密度脂蛋白（VLDL）+低密度脂蛋白（LDL）亚组分升高，高密度脂蛋白胆固醇降低。胰岛素治疗两个月后，随着HbA1a-c的下降，高密度脂蛋白胆固醇升高，甘油三酯水平下降。得出结论，高密度脂蛋白胆固醇是糖尿病初始治疗期间代谢控制的良好指标。在长期接受治疗的患者中，代谢控制与高密度脂蛋白胆固醇之间不存在如此简单的关系，每日胰岛素剂量似乎在血浆高密度脂蛋白胆固醇的调节中起重要作用。
