原钒酸盐对分离的大鼠肝细胞中脂肪酸合成的影响。
The effects of orthovanadate on fatty acid synthesis in isolated rat hepatocytes.
作者信息
Agius L, Vaartjes W J
出版信息
Biochem J. 1982 Mar 15;202(3):791-4. doi: 10.1042/bj2020791.
Abstract
Extracellular Ca2+ stimulated fatty acid synthesis in isolated rat hepatocytes. Orthovanadate (0.2--2.0 mM), an inhibitor of Ca2+-dependent ATPases, stimulated fatty acid synthesis in both the presence and the absence of extracellular Ca2+. Insulin stimulated fatty acid synthesis only in the presence of extracellular Ca2+. The contribution of extracellular Ca2+ to insulin stimulation of fatty acid synthesis is discussed.
摘要
细胞外钙离子可刺激分离的大鼠肝细胞中的脂肪酸合成。原钒酸盐（0.2 - 2.0 mM），一种钙离子依赖性ATP酶的抑制剂，在有和没有细胞外钙离子存在的情况下均能刺激脂肪酸合成。胰岛素仅在细胞外钙离子存在时刺激脂肪酸合成。本文讨论了细胞外钙离子对胰岛素刺激脂肪酸合成的作用。
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