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中链或长链三酰甘油可快速抑制泌乳大鼠乳腺体内的脂肪生成，而胰岛素可部分逆转这种抑制作用。

Rapid inhibition of lipogenesis in vivo in lactating rat mammary gland by medium- or long-chain triacylglycerols and partial reversal by insulin.

作者信息

Agius L, Williamson D H

出版信息

Biochem J. 1980 Oct 15;192(1):361-4. doi: 10.1042/bj1920361.

DOI:10.1042/bj1920361
PMID:7030306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1162342/
Abstract

An intragastric load of medium- or long-chain triacylglycerols inhibited lipogenesis in lactating rat mammary gland in vivo by 82 or 89% respectively. This inhibition was reversed partially by insulin administration. Long-chain triacylglycerols inhibited hepatic lipogenesis in vivo but medium-chain triacylglycerols increased it 2-fold. Glucose utilization in vitro by mammary gland acini from triacylglycerol-fed rat was normal.

摘要

胃内给予中链或长链三酰甘油分别使泌乳大鼠乳腺中的脂肪生成在体内受到82%或89%的抑制。胰岛素给药可部分逆转这种抑制作用。长链三酰甘油在体内抑制肝脏脂肪生成，但中链三酰甘油使其增加了2倍。来自喂食三酰甘油大鼠的乳腺腺泡在体外的葡萄糖利用正常。

相似文献

1
Rapid inhibition of lipogenesis in vivo in lactating rat mammary gland by medium- or long-chain triacylglycerols and partial reversal by insulin.中链或长链三酰甘油可快速抑制泌乳大鼠乳腺体内的脂肪生成，而胰岛素可部分逆转这种抑制作用。
Biochem J. 1980 Oct 15;192(1):361-4. doi: 10.1042/bj1920361.
2
Impaired lipogenesis in mammary glands of lactating rats fed on a cafeteria diet. Reversal of inhibition of glucose metabolism in vitro by insulin.喂食自选饮食的泌乳大鼠乳腺中脂肪生成受损。胰岛素在体外逆转葡萄糖代谢抑制作用。
Biochem J. 1980 Mar 15;186(3):1005-8. doi: 10.1042/bj1861005.
3
Effects of inhibition of protein synthesis by cycloheximide on lipogenesis in mammary gland and liver of lactating rats.放线菌酮抑制蛋白质合成对泌乳大鼠乳腺和肝脏脂肪生成的影响。
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4
Control of glucose metabolism in isolated acini of the lactating mamary gland of the rat. Effects of oleate on glucose utilization and lipogenesis.大鼠泌乳期乳腺分离腺泡中葡萄糖代谢的调控。油酸对葡萄糖利用和脂肪生成的影响。
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Regulation of peripheral lipogenesis by glucagon. Inability of the hormone to inhibit lipogenesis in rat mammary acini in vitro in the presence or absence of agents which alter its effects on adipocytes.胰高血糖素对外周脂肪生成的调节。在存在或不存在改变其对脂肪细胞作用的试剂的情况下，该激素在体外无法抑制大鼠乳腺腺泡中的脂肪生成。
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Regulation of lactating-rat mammary-gland lipogenesis by insulin and glucagon in vivo. The role and site of action of insulin in the transition to the starved state.胰岛素和胰高血糖素对泌乳大鼠乳腺脂肪生成的体内调节。胰岛素在转变为饥饿状态过程中的作用及作用位点。
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The regulation of lipogenesis in vivo in the lactating mammary gland of the rat during the starved-refed transition. Studies wtih acarbose, a glucosidase inhibitor.饥饿-再喂养过渡期大鼠泌乳乳腺体内脂肪生成的调节。使用阿卡波糖（一种葡萄糖苷酶抑制剂）的研究。
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8
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Role of pyruvate dehydrogenase and insulin in the regulation of lipogenesis in the lactating mammary gland of the rat during the starved-refed transition.饥饿-再喂养过渡期大鼠泌乳乳腺中丙酮酸脱氢酶和胰岛素在脂肪生成调节中的作用
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Polymyxin B diminishes blood flow to brown adipose tissue and lactating mammary gland in the rat. Possible mechanism of its action to decrease the stimulation of lipogenesis on refeeding.多粘菌素B可减少大鼠棕色脂肪组织和泌乳乳腺的血流量。其作用机制可能是减少再喂养时对脂肪生成的刺激。
Biochem J. 1989 Jul 15;261(2):445-50. doi: 10.1042/bj2610445.

引用本文的文献

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The effects of orthovanadate on fatty acid synthesis in isolated rat hepatocytes.原钒酸盐对分离的大鼠肝细胞中脂肪酸合成的影响。
Biochem J. 1982 Mar 15;202(3):791-4. doi: 10.1042/bj2020791.
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The effect of starvation and refeeding on lipogenic enzymes in mammary glands and livers of lactating rats.饥饿和再喂养对泌乳大鼠乳腺和肝脏中脂肪生成酶的影响。
Biochem J. 1983 Nov 15;216(2):515-8. doi: 10.1042/bj2160515.
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Biochem J. 1984 Feb 15;218(1):213-9. doi: 10.1042/bj2180213.
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Cyclic AMP phosphodiesterase and cyclic GMP phosphodiesterase activities of rat mammary tissue.大鼠乳腺组织的环磷酸腺苷磷酸二酯酶和环磷酸鸟苷磷酸二酯酶活性
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本文引用的文献

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The effect of dietary fat on fatty acid synthesis in cell-free preparations of lactating mammary gland.膳食脂肪对泌乳期乳腺无细胞制剂中脂肪酸合成的影响。
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INFLUENCE OF MEDIUM-CHAIN TRIGLYCERIDE (MCT) ON CHOLESTEROL METABOLISM IN RATS.中链甘油三酯（MCT）对大鼠胆固醇代谢的影响
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THE COMPOSITION AND BIOSYNTHESIS OF MILK LIPIDS.乳脂的组成与生物合成
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Biochem J. 1980 Apr 15;188(1):61-5. doi: 10.1042/bj1880061.
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Impaired lipogenesis in mammary glands of lactating rats fed on a cafeteria diet. Reversal of inhibition of glucose metabolism in vitro by insulin.喂食自选饮食的泌乳大鼠乳腺中脂肪生成受损。胰岛素在体外逆转葡萄糖代谢抑制作用。
Biochem J. 1980 Mar 15;186(3):1005-8. doi: 10.1042/bj1861005.
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Lipogenesis in interscapular brown adipose tissue of virgin, pregnant and lactating rats. The effects of intragastric feeding.处女、怀孕和哺乳期大鼠肩胛间棕色脂肪组织中的脂肪生成。胃内喂养的影响。
Biochem J. 1980 Aug 15;190(2):477-80. doi: 10.1042/bj1900477.
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Metabolic consequences of dietary medium-chain triglycerides in the rat.大鼠膳食中链甘油三酯的代谢后果
J Nutr. 1973 Jun;103(6):829-35. doi: 10.1093/jn/103.6.829.
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Evidence for a role of insulin in the regulation of lipogenesis in lactating rat mammary gland. Measurements of lipogenesis in vivo and plasma hormone concentrations in response to starvation and refeeding.胰岛素在泌乳大鼠乳腺脂肪生成调节中作用的证据。饥饿和再喂养后体内脂肪生成及血浆激素浓度的测定。
Biochem J. 1978 Oct 15;176(1):343-6. doi: 10.1042/bj1760343.
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Influence of dietary fat, fasting, and acute premature weaning on in vivo rates of fatty acid synthesis in lactating mice.
Proc Soc Exp Biol Med. 1978 Nov;159(2):308-12. doi: 10.3181/00379727-159-40338.