中链或长链三酰甘油可快速抑制泌乳大鼠乳腺体内的脂肪生成，而胰岛素可部分逆转这种抑制作用。
Rapid inhibition of lipogenesis in vivo in lactating rat mammary gland by medium- or long-chain triacylglycerols and partial reversal by insulin.
作者信息
Agius L, Williamson D H
出版信息
Biochem J. 1980 Oct 15;192(1):361-4. doi: 10.1042/bj1920361.
Abstract
An intragastric load of medium- or long-chain triacylglycerols inhibited lipogenesis in lactating rat mammary gland in vivo by 82 or 89% respectively. This inhibition was reversed partially by insulin administration. Long-chain triacylglycerols inhibited hepatic lipogenesis in vivo but medium-chain triacylglycerols increased it 2-fold. Glucose utilization in vitro by mammary gland acini from triacylglycerol-fed rat was normal.
摘要
胃内给予中链或长链三酰甘油分别使泌乳大鼠乳腺中的脂肪生成在体内受到82%或89%的抑制。胰岛素给药可部分逆转这种抑制作用。长链三酰甘油在体内抑制肝脏脂肪生成，但中链三酰甘油使其增加了2倍。来自喂食三酰甘油大鼠的乳腺腺泡在体外的葡萄糖利用正常。
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本文引用的文献
1
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Lipids. 1966 Jan;1(1):76-80. doi: 10.1007/BF02668127.
2
INFLUENCE OF MEDIUM-CHAIN TRIGLYCERIDE (MCT) ON CHOLESTEROL METABOLISM IN RATS.中链甘油三酯（MCT）对大鼠胆固醇代谢的影响
J Nutr. 1965 May;86(1):67-72. doi: 10.1093/jn/86.1.67.
3
THE COMPOSITION AND BIOSYNTHESIS OF MILK LIPIDS.乳脂的组成与生物合成
J Lipid Res. 1963 Jul;4:237-54.
4
Biosynthesis of fatty acids in cell-free preparations. 5. Synthesis of fatty acids from acetate in extracts of lactating-rat mammary gland.无细胞制剂中脂肪酸的生物合成。5. 泌乳大鼠乳腺提取物中由乙酸盐合成脂肪酸
Biochem J. 1962 Apr;83(1):41-51. doi: 10.1042/bj0830041.
5
Dietary regulation of mammary lipogenesis in lactating rats.泌乳大鼠乳腺脂肪生成的饮食调节
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6
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7
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Proc Soc Exp Biol Med. 1978 Nov;159(2):308-12. doi: 10.3181/00379727-159-40338.
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